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Science, New Series, Vol. 278, No. 5340, Nov. 7, 1997


Previous Issue: New Series, Vol. 278, No. 5339, Oct. 31, 1997
Next Issue: New Series, Vol. 278, No. 5341, Nov. 14, 1997


Front Matter (35 pp.)
Editorial: Cancer: What Should be Done?, p. 995
J. Michael Bishop


Letters
High Over the Permafrost, p. 997
Vanessa Winchester
Restoring Ecosystems, pp. 997-1001
Wayne Richter; James Aronson; Richard Hobbs; Arthur M. Shapiro; Andy P. Dobson; A. D. Bradshaw; Jim Baker
Rise in Asthma Cases, p. 1001
Thomas A. E. Platts-Mills; Judith A. Woodfolk


Corrections and Clarifications: Odd Visitor from the Oort Cloud, p. 1001
ScienceScope, p. 1003
Jocelyn Kaiser


News and Comment
Apocalypse Not, pp. 1004-1006
Gary Taubes
NIH Plans One Grant for All Sizes, p. 1006
Eliot Marshall
Universities Balk at OMB Funding Rules, p. 1007
Eliot Marshall
Storm Aborts Antarctic Drilling Project, pp. 1007-1008
Richard Stone
Making the Most of a Short Life, p. 1008
Gretchen Vogel
Academics Fear Research Cuts to Pay Overhead Costs, p. 1009
Nigel Williams


Research News
The Dial-Up Sky, pp. 1010-1012
Ann Finkbeiner
X-rays Hint at Space Pirouette, pp. 1012-1013
James Glanz
Fast-Forward Aging in a Mutant Mouse?, p. 1013
Wade Roush
NMR Maps Giant Molecules as they Fold and Flutter, pp. 1014-1015
Michael Balter
Lining Up Proteins for NMR, pp. 1015-1016
Robert F. Service
Rain Forest Fragments Fare Poorly, p. 1016
Nigel Williams
Growth, Death, and Climate Featured in Salt Lake City, pp. 1017-1018
Richard A. Kerr


Random Samples, pp. 1019-1021
Constance Holden


Frontiers in Cancer Research
[Introduction], p. 1035
Paula Kiberstis; Jean Marx


News
From Bench Top to Bedside, pp. 1036-1039
Marcia Barinaga
On the Biotech Pharm, a Race to Harvest New Cancer Cures, pp. 1039-1040
Wade Roush
Systems for Identifying New Drugs are Often Faulty, pp. 1041-1042
Trisha Gura

Human Cancer Syndromes: Clues to the Origin and Nature of Cancer, pp. 1043-1050
Eric R. Fearon
Genetic Testing for Cancer Risk, pp. 1050-1054
Bruce Ponder
Nucleic Acid-Based Methods for the Detection of Cancer, pp. 1054-1058
David Sidransky
Oncogenic Transcription Factors in the Human Acute Leukemias, pp. 1059-1064
A. Thomas Look
Integrating Genetic Approaches into the Discovery of Anticancer Drugs, pp. 1064-1068
Leland H. Hartwell; Philippe Szankasi; Christopher J. Roberts; Andrew W. Murray; Stephen H. Friend
Environment and Cancer: Who are Susceptible?, pp. 1068-1073
Frederica P. Perera
Recent Advances in Chemoprevention of Cancer, pp. 1073-1077
Waun Ki Hong; Michael B. Sporn


Book Reviews
The Machine Age in Medicine, p. 1082
Beginnings Count. The Technological Imperative in American Health Care.
David J. Rothman
Review author[s]: Richard A. Rettig
An Incipient Synthesis, p. 1083
Patterns and Processes of Vertebrate Evolution.
Robert L. Carroll
Review author[s]: Kevin Padian


Perspectives
Drilling Volcanoes, pp. 1084-1085
John C. Eichelberger
Death by Lethal Injection, pp. 1085-1086
Thomas J. Silhavy
Ion Channels and Locomotion, pp. 1087-1088
Sten Grillner
Quantum Nondemolition: Probing the Mystery of Quantum Mechanics, pp. 1088-1089
Stephen R. Friberg


Webwatch, p. 1089
David Voss


Policy Forum
An Environmental Rationale for Retention of Endangered Chemicals, pp. 1090-1091
Donald J. Wuebbles; James M. Calm


Research Articles
Mapping the Inside of the Ribosome with an RNA Helical Ruler, pp. 1093-1098
Simpson Joseph; Bryn Weiser; Harry F. Noller
Age and Origin of the Moon, pp. 1098-1103
Der-Chuen Lee; Alex N. Halliday; Gregory A. Snyder; Lawrence A. Taylor


Reports
Observed Hemispheric Asymmetry in Global Sea Ice Changes, pp. 1104-1106
D. J. Cavalieri; P. Gloersen; C. L. Parkinson; J. C. Comiso; H. J. Zwally
Abiotic Selenium Redox Transformations in the Presence of Fe(II,III) Oxides, pp. 1106-1109
S. C. B. Myneni; T. K. Tokunaga; G. E. Brown Jr.
High-Pressure Transformation of AI2O3, pp. 1109-1111
Nobumasa Funamori; Raymond Jeanloz
Direct Measurement of Distances and Angles in Biomolecules by NMR in a Dilute Liquid Crystalline Medium, pp. 1111-1114
Nico Tjandra; Ad Bax
Lake Baikal Record of Continental Climate Response to Orbital Insolation During the Past 5 Million Years, pp. 1114-1117
D. F. Williams; J. Peck; E. B. Karabanov; A. A. Prokopenko; V. Kravchinsky; J. King; M. I. Kuzmin
Biomass Collapse in Amazonian Forest Fragments, pp. 1117-1118
William F. Laurance; Susan G. Laurance; Leandro V. Ferreira; Judy M. Rankin-de Merona; Claude Gascon; Thomas E. Lovejoy
A Euryarchaeal Lysyl-tRNA Synthetase: Resemblance to Class I Synthetases, pp. 1119-1122
Michael Ibba; Susan Morgan; Alan W. Curnow; David R. Pridmore; Ute C. Vothknecht; Warren Gardner; Winston Lin; Carl R. Woese; Dieter Soll
Role of Sensory-Evoked NMDA Plateau Potentials in the Initiation of Locomotion, pp. 1122-1125
Gonzalo Viana Di Prisco; Edouard Pearlstein; Richard Robitaille; Réjean Dubuc
Structural Plasticity in Remodeled Protein-Protein Interface, pp. 1125-1128
Shane Atwell; Mark Ultsch; Abraham M. De Vos; James A. Wells
A Low-Barrier Hydrogen Bond in the Catalytic Triad of Serine Proteases? Theory Versus Experiment, pp. 1128-1132
Elissa L. Ash; James L. Sudmeier; Edward C. De Fabo; William W. Bachovchin
Inhibition of Brain Gz GAP and Other RGS Proteins by Palmitoylation of G Protein a Subunits, pp. 1132-1135
Yaping Tu; Jun Wang; Elliott M. Ross
Areal Segregation of Face-Processing Neurons in Prefrontal Cortex, pp. 1135-1138
Seamas P. Ó Scalaidhe; Fraser A. W. Wilson; Patricia S. Goldman-Rakic
Thermoregulation in the Mouths of Feeding Gray Whales, pp. 1138-1139
John E. Heyning; James G. Mead
A mRNA Signal for the Type III Secretion of Yop Proteins by Yersinia enterocolitica, pp. 1140-1143
Deborah M. Anderson; Olaf Schneewind


Back Matter (49 pp.)

Previous Issue: New Series, Vol. 278, No. 5339, Oct. 31, 1997
Next Issue: New Series, Vol. 278, No. 5341, Nov. 14, 1997



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