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Science, New Series, Vol. 261, No. 5123, Aug. 13, 1993


Previous Issue: New Series, Vol. 261, No. 5122, Aug. 6, 1993
Next Issue: New Series, Vol. 261, No. 5124, Aug. 20, 1993


Front Matter (21 pp.)
Editorial: Computing in Science, p. 811
John I. Brauman


Letters
Disposing of Weapons-Grade Plutonium, p. 813
Edwin Lyman; Frans Berkhout; Harold Feiveson
Fisheries Management, pp. 813-814
William Aron; David Fluharty; Donald McCaughran; John F. Roos
Determining Carcinogenicity, pp. 814-815
H. Vainio; B. Armstrong; L. Tomatis
Choose Your Poison, pp. 815-816
David Rosenberger


ScienceScope, p. 819
Richard Stone


News and Comment
Varmus Tapped to Head NIH, pp. 820+821-822
Eliot Marshall
How Varmus Got the Job, p. 821
Jon Cohen
DOE Pulls Plug on SSC Contractor, pp. 822-823
Christopher Anderson
Report Takes Aim at 50 New Projects, p. 823
Jeffrey Mervis
Army Clears Redfield-But Fails to Resolve Controversy, pp. 824-825
Jon Cohen


Random Samples, pp. 826-827
Ivan Amato


Research News
New Piece in Alzheimer's Puzzle, pp. 828-829
John Travis
Protein Signals Frog Embryo to Start Getting a Head, p. 830
Traci Watson
How Collapsing Stars Might Hide Their Tracks in Black Holes, pp. 831-832
Gary Taubes
Artificial Atom Unveils Quantum Effects, p. 832
Faye Flam
Things Start Getting Sticky For a Cell Surface Enzyme, p. 833
Felix Eijgenraam


Special Section: Computing in Science


News Reports
Beyond Databases and E-Mail, pp. 841-843
Robert Pool
AI Helps Researchers Find Meaning in Molecules, pp. 844-845
David Freedman
Fitting Planet Earth Into a User-Friendly Database, pp. 846+848
Eliot Marshall
ERS-1: A Cautionary Tale of Data Overload, p. 847
Daniel Clery
Frustrated With Fortran? Bored by Basic? Try OOP!, pp. 849-850
M. Mitchell Waldrop


Perspectives
The Ever-Present Packaging Challenge, pp. 851-852
Lloyd M. Thorndyke; John P. Riganati
Workstation Clusters Rise and Shine, pp. 852-853
Bill Buzbee
The Collaboratory Opportunity, pp. 854-855
Wm. A. Wulf


Parallel Scientific Computation, pp. 856-863
W. Daniel Hillis; Bruce M. Boghosian

Microprocessors: From Desktops to Supercomputers, pp. 864-871
Forest Baskett; John L. Hennessy

Genetic Algorithms: Principles of Natural Selection Applied to Computation, pp. 872-878
Stephanie Forrest


Research Article
Metal Ion-Dependent Modulation of the Dynamics of a Designed Protein, pp. 879-885
Tracy M. Handel; Scott A. Williams; William F. DeGrado


Reports
Reversible Rotation of Antimony Dimers on the Silicon (001) Surface with a Scanning Tunneling Microscope, pp. 886-888
Y. W. Mo
Multiple Ion Association in Supercritical Aqueous Solutions of Single Electrolytes, pp. 888-891
Eric H. Oelkers; Harold C. Helgeson
Protein Catalysis of the Retinal Subpicosecond Photoisomerization in the Primary Process of Bacteriorhodopsin Photosynthesis, pp. 891-894
Li Song; M. A. El-Sayed; J. K. Lanyi
Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip, pp. 895-897
D. Jed Harrison; Karl Fluri; Kurt Seiler; Zhonghui Fan; Carlo S. Effenhauser; Andreas Manz
High-Density Nanosecond Charge Trapping in Thin Films of the Photoconductor ZnODEP, pp. 897-899
Chong-Yang Liu; Horng-Long Pan; Marye Anne Fox; Allen J. Bard
Electron Diffraction and Imaging of Uncompressed Monolayers of Amphiphilic Molecules on Vitreous and Hexagonal Ice, pp. 899-902
J. Majewski; L. Margulis; D. Jacquemain; F. Leveiller; C. Böhm; T. Arad; Y. Talmon; M. Lahav; L. Leiserowitz
Early and Late Alkali Igneous Pulses and a High-3He Plume Origin for the Deccan Flood Basalts, pp. 902-906
Asish R. Basu; Paul R. Renne; Deb K. DasGupta; Friedrich Teichmann; Robert J. Poreda
Influence of Productivity on the Stability of Real and Model Ecosystems, pp. 906-908
John C. Moore; Peter C. de Ruiter; H. William Hunt
Determinants of Binding-Site Specificity Among Yeast C6 Zinc Cluster Proteins, pp. 909-911
Richard J. Reece; Mark Ptashne
Development of Mature CD8+ Thymocytes: Selection Rather Than Instruction?, pp. 911-915
Joost P. M. van Meerwijk; Ronald N. Germain
Reconstitution of T Cell Receptor ζ-Mediated Calcium Mobilization in Nonlymphoid Cells, pp. 915-918
Craig G. Hall; Jaime Sancho; Cox Terhorst
T Cell Development in Mice That Lack the ζ Chain of the T Cell Antigen Receptor Complex, pp. 918-921
Paul E. Love; Elizabeth W. Shores; Mark D. Johnson; Michel L. Tremblay; Eric J. Lee; Alexander Grinberg; Sing Ping Huang; Alfred Singer; Heiner Westphal
Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families, pp. 921-923
E. H. Corder; A. M. Saunders; W. J. Strittmatter; D. E. Schmechel; P. C. Gaskell; G. W. Small; A. D. Roses; J. L. Haines; M. A. Pericak-Vance


Technical Comments
Composition Limits of FexO and the Earth's Lower Mantle, pp. 923-925
Raymond Jeanloz; Robert M. Hazen; Catherine McCammon
Simplifications of a Self-Replication Model, p. 925
Kelly P. Williams


Book Reviews
Non-Degenerates, pp. 927-928
Parascript. Parasites and the Language of Evolution.
Daniel R. Brooks; Deborah A. McLennan
Review author[s]: Steven A. Nadler
Multisensory Integration, pp. 928-929
The Merging of the Senses.
Barry E. Stein; M. Alex Meredith
Review author[s]: Andrew J. King
Interpreting Europe, pp. 929-930
A Continent Revealed. The European Geotraverse.
Derek Blundell; Roy Freeman; Stephan Mueller; Sue Button
Review author[s]: Pierre Choukroune
Reprints of Books Previously Reviewed, p. 930
Books Received, p. 930


Back Matter (26 pp.)

Previous Issue: New Series, Vol. 261, No. 5122, Aug. 6, 1993
Next Issue: New Series, Vol. 261, No. 5124, Aug. 20, 1993



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