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Science, New Series, Vol. 258, No. 5079, Genome Issue, Oct. 2, 1992


Previous Issue: New Series, Vol. 257, No. 5078, Sep. 25, 1992
Next Issue: New Series, Vol. 258, No. 5080, Oct. 9, 1992


Front Matter (29 pp.)
Editorial: Genome Delight, p. 11
Barbara R. Jasny


Letters
Top Quark Search, pp. 13-14
Oscar Hernández; Krzysztof Sliwa
Detecting Explosives, pp. 14-15
A. DeVolpi; E. A. Rhodes
NSF's New Home, p. 15
William E. Cooper
Epistemology and Anthropology, pp. 15-16
Andrew J. Forester
AAUP's Role, p. 16
Leon Eisenberg


Corrections and Clarifications: Is the Wolf Finally at the Door?, p. 16
ScienceScope, p. 19
Richard Stone


News and Comment
Making Less Do More at NASA, pp. 20-22
Eliot Marshall
George Brown Cuts Into Academic Pork, p. 22
Eliot Marshall
An Uncertain Start for a Brain Decade, p. 23
Peter Aldhous
Royal Society Suggests Remedies, pp. 23-24
Peter Aldhous
Cut Off From the Mainstream, Ukrainian Science Drifts, pp. 24-26
Steven Dickman
Correction: Agencies Split on Nutrition Advice, p. 26
SETI Faces Uncertainty on Earth and in the Stars, p. 27
Richard A. Kerr


Research News
Two Chromosomes Down, 22 to Go, pp. 28+30
Leslie Roberts
French Genome Project on Track at Last, p. 29
Peter Aldhous
Can a Father's Exposure Lead To Illness in his Children?, p. 31
Richard Stone
Coupled States Clear the Darkness and Quiet the Light, pp. 32-33
Neal Singer


Random Samples, pp. 34-35


Perspectives
Hidden Messages in Genetic Maps, p. 49
Christine J. Farr; Peter N. Goodfellow
Calmodulin and Myosin Light Chain Kinase: How Helices Are Bent, pp. 50-51
Robert H. Kretsinger


Research Articles
The Human Y Chromosome: A 43-Interval Map Based on Naturally Occurring Deletions, pp. 52-59
Douglas Vollrath; Simon Foote; Adrienne Hilton; Laura G. Brown; Peggy Beer-Romero; Jonathan S. Bogan; David C. Page
The Human Y Chromosome: Overlapping DNA Clones Spanning the Euchromatic Region, pp. 60-66
Simon Foote; Douglas Vollrath; Adrienne Hilton; David C. Page


A Comprehensive Genetic Linkage Map of the Human Genome, pp. 67-86
NIH/CEPH Collaborative Mapping Group

Genome Maps III, pp. 87-102
Jean-Louis Mandel; Anthony P. Monaco; David L. Nelson; David Schlessinger; Huntington F. Willard; Michael Chipperfield; Peter Pearson; Paul Gilna; Michael Cinkosky

Genome Analysis and the Human X Chromosme, pp. 103-109
Jean-Louis Mandel; Anthony P. Monaco; David L. Nelson; David Schlessinger; Huntington Willard


Reports
Time and Metamorphic Petrology: Calcite to Aragonite Experiments, pp. 110-112
B. R. Hacker; S. H. Kirby; S. R. Bohlen
An Experiment-Based Model for the Petrogenesis of High-Alumina Basalts, pp. 112-115
J. S. Beard; G. E. Lofgren
Sensitivity of Glaciers and Small Ice Caps to Greehouse Warming, pp. 115-117
J. Oerlemans; J. P. F. Fortuin
Sulfate Cooling Effect on Climate Through In-Cloud Oxidation of Anthropogenic SO2, pp. 117-120
Jos Lelieveld; Jost Heintzenberg
Immuno-PCR: Very Sensitive Antigen Detection by Means of Specific Antibody- DNA Conjugates, pp. 120-122
Takeshi Sano; Cassandra L. Smith; Charles R. Cantor
The B Cell Antigen Receptor Complex: Association of Ig-α and Ig-β with Distinct Cytoplasmic Effectors, pp. 123-126
Marcus R. Clark; Kerry S. Campbell; Andrius Kazlauskas; Sara A. Johnson; Marc Hertz; Terry A. Potter; Chris Pleiman; John C. Cambier
Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing, pp. 126-129
Mikio Shoji; Todd E. Golde; Jorge Ghiso; Tobun T. Cheung; Steven Estus; Lillian M. Shaffer; Xiao-Dan Cai; Deborah M. McKay; Ron Tintner; Blas Frangione; Steven G. Younkin
Structural Basis of the Intrasteric Regulation of Myosin Light Chain Kinases, pp. 130-135
Daniel R. Knighton; Richard B. Pearson; Janusz M. Sowadski; Anthony R. Means; Lynn F. Ten Eyck; Susan S. Taylor; Bruce E. Kemp
Lack of Protective Immunity Against Reinfection with Hepatitis C Virus, pp. 135-140
Patrizia Farci; Harvey J. Alter; Sugantha Govindarajan; Doris C. Wong; Ronald Engle; Richard R. Lesniewski; Isa K. Mushahwar; Suresh M. Desai; Roger H. Miller; Norio Ogata; Robert H. Purcell


Book Reviews
A Celebration in Chemistry, pp. 143-144
The Chemical Bond. Structure and Dynamics.
Ahmed Zewail
Review author[s]: David Dixon
Axons, Ions, and Dons, pp. 144-145
Chance and Design. Reminiscences of Science in Peace and War.
Alan Hodgkin
Review author[s]: Bertil Hille
Astronomical Objects, pp. 145-146
Variability of Blazars.
Esko Valtaoja; Mauri Valtonen
Review author[s]: K. I. Kellermann
Books Received, p. 146


Appendix: A Comprehensive Genetic Linkage Map of the Human Genome, pp. 148-162
NIH/CEPH Colloborative Mapping Group

Back Matter (27 pp.)

Previous Issue: New Series, Vol. 257, No. 5078, Sep. 25, 1992
Next Issue: New Series, Vol. 258, No. 5080, Oct. 9, 1992



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