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Science, New Series, Vol. 262, No. 5142, Dec. 24, 1993


Previous Issue: New Series, Vol. 262, No. 5141, Dec. 17, 1993
Next Issue: New Series, Vol. 263, No. 5143, Jan. 7, 1994


Volume Information (13 pp.)
Front Matter (9 pp.)
Editorial: Molecule of the Year, p. 1953
Daniel E. Koshland Jr.


Letters
Elimination of Scholarships, p. 1954
Sue Ann Lewandowski; Peter H. Klopfer
Women in Biomedicine, pp. 1954-1955
Laura I. Davis; Ann Marie White
Bottleneck in Human Evolution and the Toba Eruption, p. 1955
Michael R. Rampino; Stephen Self
The Baucus Bill, pp. 1955-1956
Michael O. Woodburne
Ice Man's Fungi: Discussion Rekindled, p. 1956
Reinhold Pöder
Manson Crater Extinctions, pp. 1956-1957
Dale A. Russell
Language and Math, p. 1957
Mary S. Erbaugh


Corrections and Clarifications: Lack of N Regions in Antigen Receptor Variable Region Genes of TdT-Deficient Lymphocytes, p. 1957
Corrections and Clarifications: Mice Lacking in TdT: Mature Animals with an Immature Lymphocyte Repertoire, p. 1957
p53 Sweeps Through Cancer Research, pp. 1958-1961
Elizabeth Culotta; Daniel E. Koshland Jr.

ScienceScope, p. 1963
Richard Stone


News and Comment
East Europe: A Chance to Stop HIV, pp. 1964-1965
Michael Balter
Will Tritium Give Magnetic Fusion a Shot in the Arm?, p. 1966
James Glanz
Draft Genome Map Debuts on Internet, p. 1967
Rachel Nowak
Fermat Proof Hits a Stumbling Block, pp. 1967-1968
Barry Cipra
Scientists Study 'Cold War' Fallout, p. 1968
Richard Stone


Research News
The Quest for the Youngest Galaxies, pp. 1969-1970
Ann Finkbeiner
HIV 'Cofactor' Comes in for More Heavy Fire, p. 1971
Jon Cohen
The Whole World had a Case of the Ice Age Shivers, pp. 1972-1973
Richard A. Kerr
Wiring for a Very Small World, p. 1973
Karen Fox
Army Targets a Potential Vaccine Against Cholesterol, pp. 1974-1975
John Travis
A Closer Look at the Dinosaur-Bird Link, p. 1975
Joshua Fischman


Random Samples, pp. 1976-1977
Constance Holden


Perspectives
Guides to the Heart of the Spliceosome, pp. 1978-1979
Jo Ann Wise
p53: At the Crossroads of Molecular Carcinogenesis and Risk Assessment, pp. 1980-1981
Curtis C. Harris


Research Articles
Mutations in U6 snRNA that Alter Splice Site Specificity: Implications for the Active Site, pp. 1982-1988
Cammie F. Lesser; Christine Guthrie
The U5 and U6 Small Nuclear RNAs as Active Site Components of the Spliceosome, pp. 1989-1996
Erik J. Sontheimer; Joan A. Steitz
A Mitochondrial Protease with Two Catalytic Subunits of Nonoverlapping Specificities, pp. 1997-2004
Jodi Nunnari; Thomas D. Fox; Peter Walter


Reports
Generation of Impossible Cross-Peaks between Bulk Water and Biomolecules in Solution NMR, pp. 2005-2009
Warren S. Warren; Wolfgang Richter; Amy Hamilton Andreotti; Bennett T. Farmer II
A Simple Kinetic Model of Polymer Adsorption and Desorption, pp. 2010-2012
Jack F. Douglas; Harry E. Johnson; Steve Granick
Molecular Light Emission Induced by Inelastic Electron Tunneling, pp. 2012-2014
Eli Flaxer; Ofer Sneh; Ori Cheshnovsky
Fabrication of Conducting Polymer Interconnects, pp. 2014-2016
Corrine L. Curtis; Jason E. Ritchie; Michael J. Sailor
Stable Isotope Enrichment in Paleowaters of the Southeast Atlantic Coastal Plain, United States, pp. 2016-2020
L. Niel Plummer
Evidence of the Growth Plate and the Growth of Long Bones in Juvenile Dinosaurs, pp. 2020-2023
Claudio Barreto; Ralph M. Albrecht; Dale E. Bjorling; John R. Horner; Norman J. Wilsman
Mantle Plume Helium in Submarine Basalts from the Galápagos Platform, pp. 2023-2026
D. W. Graham; D. M. Christie; K. S. Harpp; J. E. Lupton
Crystal Structure of the Repetitive Segments of Spectrin, pp. 2027-2030
Y. Yan; E. Winograd; A. Viel; T. Cronin; S. C. Harrison; D. Branton
A Covalent Enzyme-Substrate Intermediate with Saccharide Distortion in a Mutant T4 Lysozyme, pp. 2030-2033
Ryota Kuroki; Larry H. Weaver; Brian W. Matthews
Chromosome Condensation in Xenopus Mitotic Extracts Without Histone H1, pp. 2033-2035
Keita Ohsumi; Chiaki Katagiri; Takeo Kishimoto
Role of U6 snRNA in 5′ Splice Site Selection, pp. 2035-2039
Stefanie Kandels-Lewis; Bertrand Séraphin
Connexin Mutations in X-Linked Charcot-Marie-Tooth Disease, pp. 2039-2042
J. Bergoffen; S. S. Scherer; S. Wang; M. Oronzi Scott; L. J. Bone; D. L. Paul; K. Chen; M. W. Lensch; P. F. Chance; K. H. Fischbeck
Perceptual Organization and the Judgment of Brightness, pp. 2042-2044
Edward H. Adelson
T Cell Activation Antigen, CD26, as a Cofactor for Entry of HIV in CD4+ Cells, pp. 2045-2050
Christian Callebaut; Bernard Krust; Etienne Jacotot; Ara G. Hovanessian
Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control, pp. 2050-2054
Sander van den Heuvel; Ed Harlow
Receptive Field Reorganization in Dorsal Column Nuclei During Temporary Denervation, pp. 2054-2056
Michael J. Pettit; Harris D. Schwark
WT1-Mediated Growth Suppression of Wilms Tumor Cells Expressing a WT1 Splicing Variant, pp. 2057-2059
Daniel A. Haber; Seon Park; Shyamala Maheswaran; Christoph Englert; Gian G. Re; Debra J. Hazen-Martin; Donald A. Sens; A. Julian Garvin
Peptide Translocation by Variants of the Transporter Associated with Antigen Processing, pp. 2059-2063
Marie-Thérèse Heemels; Ton N. M. Schumacher; Kurt Wonigeit; Hidde L. Ploegh


Technical Comments
Male Sexual Orientation and Genetic Evidence, pp. 2063-2065
Neil Risch; Elizabeth Squires-Wheeler; Bronya J. B. Keats; Dean H. Hamer; Stella Hu; Victoria Magnuson; Nan Hu; Angela M. L. Pattatucci


Inside AAAS, p. 2066
Diana Pabst


Book Reviews
The Decline of Abstinence, pp. 2067-2068
Bad Habits. Drinking, Smoking, Taking Drugs, Gambling, Sexual Misbehavior, and Swearing in American History.
John C. Burnham
Review author[s]: Stephen D. Sugarman
The Age of Our Species, p. 2068
Men Among the Mammoths. Victorian Science and the Discovery of Human Prehistory.
A. Bowdoin van Riper
Review author[s]: Donald K. Grayson
Galactic Enthusiast, p. 2069
The Man Who Sold the Milky Way. A Biography of Bart Bok.
David H. Levy
Review author[s]: David H. DeVorkin
Horbigerism, pp. 2069-2070
Universal Ice. Science and Ideology in the Nazi State.
Robert Bowen
Review author[s]: Michael J. Neufeld
Nuclear Magic, pp. 2070-2071
Simple Models of Complex Nuclei. The Shell Model and Interacting Boson Model.
Igal Talmi
Review author[s]: Joseph N. Ginocchi
----------------, pp. 2071-2072
Methods in Arabidopsis Research.
Csaba Koncz; Nam-Hai Chua; Jeff Schell
Review author[s]: Peter M. Gresshoff
----------------, p. 2072
The Maize Handbook.
Michael Freeling; Virginia Walbot
Review author[s]: Katherine Livingston
Books Received, pp. 2072-2073


Back Matter (22 pp.)

Previous Issue: New Series, Vol. 262, No. 5141, Dec. 17, 1993
Next Issue: New Series, Vol. 263, No. 5143, Jan. 7, 1994



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