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Science, New Series, Vol. 287, No. 5460, Mar. 17, 2000


Previous Issue: New Series, Vol. 287, No. 5459, Mar. 10, 2000
Next Issue: New Series, Vol. 287, No. 5461, Mar. 24, 2000


Front Matter (42 pp.)
NetWatch, p. 1883
Jocelyn Kaiser

Editors' Choice, pp. 1889+1891
Gilbert Chin


News


News of the Week
SNP Mappers Confront Reality and Find It Daunting, pp. 1898-1899
Leslie Roberts
Oxford Wins a Crown Synchrotron Jewel, p. 1899
Michael Hagmann
Distorted Galaxies Point to Dark Matter, pp. 1899+1901
Adrian Cho
Cancer Researcher Sacked for Alleged Fraud, pp. 1901-1902
Michael Hagmann
ScienceScope, p. 1901
Jocelyn Kaiser; Constance Holden
Nanocrystals May Give Boost to Data Storage, pp. 1902-1903
Robert F. Service
Clinton and Blair Back Rapid Release of Data, p. 1903
Eliot Marshall
Congress Investigates Fetal Tissue Sales, pp. 1903+1905
Gretchen Vogel
Endorsement for Controversial Satellite, p. 1905
Andrew Lawler


News Focus
On the Hunt for a Wolf in Sheep's Clothing, pp. 1906-1908
Michael Balter
'Spooky Action' Passes a Relativistic Test, pp. 1909-1910
Charles Seife
Rounding out Solutions to Three Conjectures, pp. 1910-1912
Barry Cipra; Dana Mackenzie; Charles Seife
Seeing a World in Grains of Sand, pp. 1912-1913+1915
Erik Stokstad


Random Samples, p. 1917
Constance Holden


Science's Compass


Editorial
Too Much of a Good Thing?, p. 1925
Floyd E. Bloom


Letters
Transgenic Crops: A Cautionary Tale, pp. 1927-1928
Ronald Nigh; Charles Benbrook; Stephen Brush; Luis Garcia-Barrios; Rafael Ortega-Paczka; Hugo R. Perales; Shahal Abbo; Baruch Rubin
Electricity Supply, p. 1928
Alan E. Waltar
Clinical Research, p. 1928
Ralph Snyderman
Hydrogen Storage in Nanotubes, p. 1929
Jianyi Lin
Science under the Nazis, pp. 1929+1931
Jacob J. Steinberg; Manfred D. Laubichler
Corrections and Clarifications: Fermat's Last Theorem's First Cousin, p. 1931
Corrections and Clarifications: The Endless Pathways of Discovery, p. 1931
Corrections and Clarifications: Random Samples, p. 1931
Corrections and Clarifications: Modulation of Brain Reward Circuitry by Leptin, p. 1931
Corrections and Clarifications: Shadow and Shine Offer Glimpses of Otherworldly Jupiters, p. 1931


Policy Forum
Reforming the Patent System, pp. 1933-1934
John H. Barton


Books et al.
Quantum Mechanics at the End of the 20th Century, p. 1935
The Odd Quantum
Sam Treiman
Review author[s]: Hans Christian von Baeyer
Tools for Thinking, pp. 1935-1936
Models as Mediators: Perspectives on Natural and Social Science
Mary S. Morgan; Margaret Morrison
Review author[s]: Peter Imhof


Perspectives
Inositol Phosphates in the Nucleus, pp. 1937+1939
Tian H. Chi; Gerald R. Crabtree
Limbless Tetrapods and Snakes with Legs, pp. 1939-1941
Harry W. Greene; David Cundall
H3+-an Ion with Many Talents, pp. 1941-1942
Benjamin J. McCall; Takeshi Oka
Conquering the Carbon-Hydrogen Bond, pp. 1942-1943
William D. Jones
Strengthening Visual Connections, pp. 1943-1944
Max Cynader


Tech.Sight
Integrating Combinatorial Synthesis and Bioassays, pp. 1947-1948
Jörg Rademann; Günther Jung
Worldwide Weather Watcher, p. 1949
WeatherTracker
Review author[s]: Kevin Ahern
Data Tool, p. 1949
PSI-Plot
Review author[s]: William Seffens
A Picture Is Worth a Thousand Words, pp. 1949-1950
Noesys 2.0
Review author[s]: Emile M. Bellott
TechSightings, p. 1950
Linda Rowan


Drug Discovery
An Information Revolution, p. 1951
Julia Uppenbrink; Jeffrey Mervis


News
When Pharma Merges, R&D Is the Dowry, pp. 1952-1953
Bruce Agnew
Structural Genomics Offers High-Speed Look at Proteins, pp. 1954-1956
Robert F. Service
Malaria Researchers Wait for Industry to Join Fight, pp. 1956-1958
Martin Enserink
U.S., Europe, Japan Look to Speed up Drug Reviews, pp. 1958-1959
Dennis Normile; Eliot Marshall


Reviews
Drug Discovery: A Historical Perspective, pp. 1960-1964
Jürgen Drews
Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery, pp. 1964-1969
Stuart L. Schreiber
Mechanism-Based Target Identification and Drug Discovery in Cancer Research, pp. 1969-1973
Jackson B. Gibbs
Harnessing the Power of the Genome in the Search for New Antibiotics, pp. 1973-1976
John Rosamond; Aileen Allsop


Viewpoints
Genomic Medicine and the Future of Health Care, pp. 1977-1978
Chris Sander
The Global Drug Gap, pp. 1979-1981
Michael R. Reich


Research


Reports
Monodisperse FePt Nanoparticles and Ferromagnetic FePt Nanocrystal Superlattices, pp. 1989-1992
Shouheng Sun; C. B. Murray; Dieter Weller; Liesl Folks; Andreas Moser
Efficient Activation of Aromatic C-H Bonds for Addition to C-C Multiple Bonds, pp. 1992-1995
Chengguo Jia; Dongguo Piao; Juzo Oyamada; Wenjun Lu; Tsugio Kitamura; Yuzo Fujiwara
Thermal, Catalytic, Regiospecific Functionalization of Alkanes, pp. 1995-1997
Huiyuan Chen; Sabine Schlecht; Thomas C. Semple; John F. Hartwig
Detection of SO in Io's Exosphere, pp. 1998-1999
C. T. Russell; M. G. Kivelson
Secular Variation of Iron Isotopes in North Atlantic Deep Water, pp. 2000-2002
Xiang-Kun Zhu; R. Keith O'Nions; Yueling Guo; Ben C. Reynolds
Modulation of Hurricane Activity in the Gulf of Mexico by the Madden-Julian Oscillation, pp. 2002-2004
Eric D. Maloney; Dennis L. Hartmann
Contribution of Increasing CO2 and Climate to Carbon Storage by Ecosystems in the United States, pp. 2004-2006
David Schimel; Jerry Melillo; Hanqin Tian; A. David McGuire; David Kicklighter; Timothy Kittel; Nan Rosenbloom; Steven Running; Peter Thornton; Dennis Ojima; William Parton; Robin Kelly; Martin Sykes; Ron Neilson; Brian Rizzo
Cell Surface Engineering by a Modified Staudinger Reaction, pp. 2007-2010
Eliana Saxon; Carolyn R. Bertozzi
A Fossil Snake with Limbs, pp. 2010-2012
Eitan Tchernov; Olivier Rieppel; Hussam Zaher; Michael J. Polcyn; Louis L. Jacobs
Prostaglandin D2 as a Mediator of Allergic Asthma, pp. 2013-2017
Toshiyuki Matsuoka; Masakazu Hirata; Hiroyuki Tanaka; Yoshimasa Takahashi; Takahiko Murata; Kenji Kabashima; Yukihiko Sugimoto; Takuya Kobayashi; Fumitaka Ushikubi; Yoshiya Aze; Naomi Eguchi; Yoshihiro Urade; Nobuaki Yoshida; Kazushi Kimura; Akira Mizoguchi; Yoshihito Honda; Hiroichi Nagai; Shuh Narumiya
Facile Detection of Mitochondrial DNA Mutations in Tumors and Bodily Fluids, pp. 2017-2019
Makiko S. Fliss; Henning Usadel; Otávia L. Caballero; Li Wu; Martin R. Buta; Scott M. Eleff; Jin Jen; David Sidransky
Reversal of Antipsychotic-Induced Working Memory Deficits by Short-Term Dopamine D1 Receptor Stimulation, pp. 2020-2022
Stacy A. Castner; Graham V. Williams; Patricia S. Goldman-Rakic
Start Sites of Bidirectional DNA Synthesis at the Human Lamin B2 Origin, pp. 2023-2026
Gulnara Abdurashidova; Marta Deganuto; Raffaella Klima; Silvano Riva; Giuseppe Biamonti; Mauro Giacca; Arturo Falaschi
A Role for Nuclear Inositol 1,4,5-Trisphosphate Kinase in Transcriptional Control, pp. 2026-2029
Audrey R. Odom; Alke Stahlberg; Susan R. Wente; John D. York
Rapid Extragranular Plasticity in the Absence of Thalamocortical Plasticity in the Developing Primary Visual Cortex, pp. 2029-2032
Joshua T. Trachtenberg; Christopher Trepel; Michael P. Stryker
Retinal Stem Cells in the Adult Mammalian Eye, pp. 2032-2036
Vincent Tropepe; Brenda L. K. Coles; Bernard J. Chiasson; D. Jonathan Horsford; Andrew J. Elia; Roderick R. McInnes; Derek van der Kooy
Motion Integration and Postdiction in Visual Awareness, pp. 2036-2038
David M. Eagleman; Terrence J. Sejnowski


Back Matter (66 pp.)

Previous Issue: New Series, Vol. 287, No. 5459, Mar. 10, 2000
Next Issue: New Series, Vol. 287, No. 5461, Mar. 24, 2000



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