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Science, New Series, Vol. 286, No. 5448, Dec. 17, 1999


Previous Issue: New Series, Vol. 286, No. 5447, Dec. 10, 1999
Next Issue: New Series, Vol. 286, No. 5449, Dec. 24, 1999


Front Matter (28 pp.)
NetWatch, p. 2227
Jocelyn Kaiser


Breakthrough of the Year
Capturing the Promise of Youth, pp. 2238-2243
Gretchen Vogel; Constance Holden


News


News of the Week
Gene Therapy Death Prompts Review of Adenovirus Vector, pp. 2244-2245
Eliot Marshall
Promising Antibiotic Candidate Identified, pp. 2245+2247
Martin Enserink
Europe Lofts X-ray Observatory, pp. 2247-2248
Alexander Hellemans
ScienceScope, pp. 2247+2249
Mental Health Agency Shrugs Off Critics, p. 2248
Constance Holden
Changes to Missions Could Delay Science, pp. 2248-2249
Andrew Lawler; Richard Kerr
Researcher Rebuked for 20-Year-Old Misdeed, pp. 2249-2250
Michael Hagmann
Big Blue Aims to Crack Protein Riddle, p. 2250
Robert F. Service
NRC Panel to Propose Station Institute, p. 2251
Andrew Lawler
Taq Polymerase Patent Ruled Invalid, pp. 2251+2253
Robert F. Service
Licenses Suspended at 3 Toronto Hospitals, p. 2253
Wayne Kondro


News Focus
Ancient Continent Opens Window on the Early Earth, pp. 2254-2256
Carl Zimmer
Does Cancer Therapy Trigger Cell Suicide?, pp. 2256-2258
Elizabeth Finkel
Europe Stresses Prevention Rather than Cure, pp. 2258-2259
Michael Hagmann
Indian Agency Eyes Moon in Shift Toward Research, p. 2260
Pallava Bagla
Scanners Get a Fix on Lab Animals, pp. 2261+2263
Robert F. Service


Random Samples, p. 2265
Constance Holden


Science's Compass


Editorial
Breakthroughs 1999, p. 2267
Floyd E. Bloom


Letters
A Loss to Science, p. 2269
Robert J. Birgeneau
Dietary Supplements: What is in the Public's Best Interest?, pp. 2269-2271
John N. Hathcock; Shawn M. Talbott; Steven H. Zeisel
Scrutinizing Creativity, pp. 2271-2272
Dennis Hollenberg; Jacob Goldenberg; David Mazursky; Sorin Solomon
A Comb-Wide Web, pp. 2272-2273
Jürgen Tautz
Corrections and Clarifications: Whirling Dervishes, p. 2273
Corrections and Clarifications: Sexual Transmission and Propagation of SIV and HIV in Resting and Activated CD4+T Cells, p. 2273
Corrections and Clarifications: First Glimpse of a Cosmic Funnel, p. 2273
Corrections and Clarifications: Scientists Strike Back against Creationism, p. 2273
Corrections and Clarifications: Precisely Localized LTD in the Neocortex Revealed by Infrared-Guided Laser Stimulation, p. 2273
Corrections and Clarifications: A Responsible Energy Furture, p. 2273


Policy Forum
Food Irradiation-The Neglected Solution to Food-Borne Illness, pp. 2275-2276
Randall Lutter
Commercialization of Genetic Research and Public Policy, pp. 2277-2278
Bartha Maria Knoppers; Marie Hirtle; Kathleen Cranley Glass


Books et al.
Cathedrals as Astronomical Instruments, pp. 2279-2280
The Sun in the Church. Cathedrals as Solar Observatories
J. L. Heibron
Review author[s]: Albert Van Helden
A Bright View, too Focused, p. 2280
From Space to Earth. The Story of Electricity.
John Perlin
Review author[s]: David Faiman


Perspectives
Y2K, p. 2281
Christopher J. Cramer; Jeffrey T. Roberts
An Innate Basis for Language?, pp. 2283-2284
Dorothy V. M. Bishop
Mutant Dyskerin Ends Relationship with Telomerase, pp. 2284-2285
Jerry W. Shay; Woodring E. Wright
Imaging Elusive Solute Atoms, pp. 2285-2286
M. K. Miller
Toward Efficient Smart Pixels, pp. 2286-2287
Jörg P. Kotthaus
DNA Methylation de Novo, pp. 2287-2288
Adrian Bird


Tech.Sight
New Tools for Isotopic Analysis, pp. 2289-2290
Trevor Ireland
A Mathematical Swiss Army Knife, pp. 2291-2292
Mathematica 4.0.
Review author[s]: John A. Wass
Plugging in to Visual Data, p. 2293
HDF Import Plug-in Fortner Software, LLC.
Review author[s]: Kevin Ahern
Sorting on Silicon, pp. 2293-2294
Robert Sikorski; Richard Peters
Y2K or Bust, p. 2294
Richard Peters; Robert Sikorski


Vision of the Furture
Technology Transfer, pp. 2296-2298
Ruth Kohen
Appointment as Expert Juror, pp. 2298-2299
Mary Ann Krug
NIH Grant Application, pp. 2300-2301


Research


Research Article
Structure of a Transcribing T7 RNA Polymerase Initiation Complex, pp. 2305-2309
Graham M. T. Cheetham; Thomas A. Steitz


Reports
Phase-Coherent Amplification of Matter Waves, pp. 2309-2312
Mikio Kozuma; Yoichi Suzuki; Yoshio Torii; Toshiaki Sugiura; Takahiro Kuga; E. W. Hagley; L. Deng
Exciton Storage in Semiconductor Self-Assembled Quantum Dots, pp. 2312-2314
T. Lundstrom; W. Schoenfeld; H. Lee; P. M. Petroff
Experimental Tunneling Ratchets, pp. 2314-2317
H. Linke; T. E. Humphrey; A. Löfgren; A. O. Sushkov; R. Newbury; R. P. Taylor; P. Omling
Three-Dimensional Atomic-Scale Imaging of Impurity Segregation to Line Defects, pp. 2317-2319
D. Blavette; E. Cadel; A. Fraczkiewicz; A. Menand
Deflection of the Local Interstellar Dust Flow by Solar Radiation Pressure, pp. 2319-2322
M. Landgraf; K. Augustsson; E. Grün; B. Å. S. Gustafson
Short-Lived Oxygen Diffusion During Hot, Deep-Seated Meteoric Alteration of Anorthosite, pp. 2323-2325
Claudia I. Mora; Lee R. Riciputi; David R. Cole
Surfactant-Mediated Two-Dimensional Crystallization of Colloidal Crystals, pp. 2325-2328
Laurence Ramos; T. C. Lubensky; Nily Dan; Philip Nelson; D. A. Weitz
Postnatal Sex Reversal of the Ovaries in Mice Lacking Estrogen Receptors α and β, pp. 2328-2331
J. F. Couse; S. Curtis Hewitt; D. O. Bunch; M. Sar; V. R. Walker; B. J. Davis; K. S. Korach
Isolation of West Nile Virus from Mosquitoes, Crows, and a Cooper's Hawk in Connecticut, pp. 2331-2333
John F. Anderson; Theodore G. Andreadis; Charles R. Vossbrinck; Shirley Tirrell; Edward M. Wakem; Richard A. French; Antonio E. Garmendia; Herbert J. Van Kruiningen
Origin of the West Nile Virus Responsible for an Outbreak of Encephalitis in the Northeastern United States, pp. 2333-2337
R. S. Lanciotti; J. T. Roehrig; V. Deubel; J. Smith; M. Parker; K. Steele; B. Crise; K. E. Volpe; M. B. Crabtree; J. H. Scherret; R. A. Hall; J. S. MacKenzie; C. B. Cropp; B. Panigrahy; E. Ostlund; B. Schmitt; M. Malkinson; C. Banet; J. Weissman; N. Komar; H. M. Savage; W. Stone; T. McNamara; D. J. Gubler
Binding of Transcription Termination Protein Nun to Nascent RNA and Template DNA, pp. 2337-2339
Randolph S. Watnick; Max E. Gottesman
Requirement of Yeast SGS1 and SRS2 Genes for Replication and Transcription, pp. 2339-2342
Sung-Keun Lee; Robert E. Johnson; Sung-Lim Yu; Louise Prakash; Satya Prakash
Posttranscriptional Gene Silencing in Neurospora by a RecQ DNA Helicase, pp. 2342-2344
Carlo Cogoni; Giuseppe Macino
Evolution of Shape Complementarity and Catalytic Efficiency from a Primordial Antibody Template, pp. 2345-2348
Jian Xu; Qiaolin Deng; Jiangang Chen; Kendall N. Houk; Johannes Bartek; Donald Hilvert; Ian A. Wilson
Crystal Structure of Thermotoga maritima Ribosome Recycling Factor: A tRNA Mimic, pp. 2349-2352
Maria Selmer; Salam Al-Karadaghi; Go Hirokawa; Akira Kaji; Anders Liljas
Microglial Activation Resulting from CD40-CD40L Interaction After β- Amyloid Stimulation, pp. 2352-2355
Jun Tan; Terrence Town; Daniel Paris; Takashi Mori; Zhiming Suo; Fiona Crawford; Mark P. Mattson; Richard A. Flavell; Michael Mullan
Cognitive Modularity and Genetic Disorders, pp. 2355-2358
S. J. Paterson; J. H. Brown; M. K. Gsödl; M. H. Johnson; A. Karmiloff-Smith
Mediation by a CREB Family Transcription Factor of NGF-Dependent Survival of Sympathetic Neurons, pp. 2358-2361
Antonella Riccio; Sohyun Ahn; Christopher M. Davenport; Julie A. Blendy; David D. Ginty
Use of the Cell Wall Precursor Lipid II by a Pore-Forming Peptide Antibiotic, pp. 2361-2364
E. Breukink; I. Wiedemann; C. van Kraaij; O. P. Kuipers; H.-G. Sahl; B. de Kruijff


Back Matter (52 pp.)

Previous Issue: New Series, Vol. 286, No. 5447, Dec. 10, 1999
Next Issue: New Series, Vol. 286, No. 5449, Dec. 24, 1999



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