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Science, New Series, Vol. 262, No. 5139, Dec. 3, 1993


Previous Issue: New Series, Vol. 262, No. 5138, Nov. 26, 1993
Next Issue: New Series, Vol. 262, No. 5140, Dec. 10, 1993


Front Matter (17 pp.)
Editorial: Health Care: More Access and More Cures, p. 1495
Daniel E. Koshland Jr.


Letters
Medical Research: Alternative Views, p. 1497
Richard D. Lamm; Philippe Grandjean
Dioxin Exposure, p. 1498
James J. Collins
Genetics and Crime, p. 1498
Peter R. Breggin
A Life-Saving Accelerator, pp. 1498-1499
Stanley M. Flatté
For the Greater Good, p. 1499
J. R. Dorfman
Cyclic ADP-Ribose and Pancreatic β Cells, p. 1499
Md. Shahidul Islam; Olof Larsson; Per-Olof Berggren


Corrections and Clarifications: Light Microscopes get a Sharper Look, p. 1499
Corrections and Clarifications: Skn-1a and Skn-li: Two Functionally Distinct Oct-2-Related Factors Expressed in Epidermis, p. 1499
Corrections and Clarifications: Metalloenzymes, Structural Motifs, and Inorganic Models, p. 1499


Policy Forum
Serious Flaws in the Horizontal Approach to Biotechnology Risk, pp. 1500-1501
Henry I. Miller; Douglas Gunary


ScienceScope, p. 1503
Richard Stone


News and Comment
Laser Fusion Catches Fire, pp. 1504-1506
Gary Taubes
Fight Heats Up Over SSC's Remains, pp. 1506-1507
Gary Taubes
Debating the Use of Transgenic Predators, p. 1507
Billy Goodman
Prevention Research: A New Growth Area for NIH?, pp. 1508-1509
Eliot Marshall
Race to Grow Hantavirus Ends in Tie, p. 1509
Eliot Marshall; Richard Stone


Random Samples, pp. 1510-1511
Constance Holden


Research News
Ribozymes: Killing the Messenger, pp. 1512-1514
Marcia Barinaga
An Avian Arch-Villain Gets Off Easy, pp. 1514-1515
Bob Holmes
Isotope Makers Grab Hold of the Rock, pp. 1515-1516
Daniel Clery
Superconductor as Movie Star, p. 1516
Robert Pool
New Clues Surface About The Making of the Mind, p. 1517
Joshua Fischman


Perspectives
Probing Ice Sheets with Imaging Radar, pp. 1521-1522
R. Keith Raney
Closing in on SH2 Specificity, pp. 1522-1524
Raymond B. Birge; Hidesaburo Hanafusa


Satellite Radar Interferometry for Monitoring Ice Sheet Motion: Application to an Antarctic Ice Stream, pp. 1525-1530
Richard M. Goldstein; Hermann Engelhardt; Barclay Kamb; Richard M. Frolich

Greenland Ice Sheet Surface Properties and Ice Dynamics from ERS-1 SAR Imagery, pp. 1530-1534
Mark Fahnestock; Robert Bindschadler; Ron Kwok; Ken Jezek


Research Article
Enzymatic Synthesis of a Bacterial Polyketide from Acetyl and Malonyl Coenzyme A, pp. 1535-1540
Ben Shen; C. Richard Hutchinson


Reports
Discovery of a Main-Belt Asteroid Resembling Ordinary Chondrite Meteorites, pp. 1541-1543
Richard P. Binzel; Shui Xu; Schelte J. Bus; M. F. Skrutskie; Michael R. Meyer; Patricia Knezek; Edwin S. Barker
SSZ-26 and SSZ-33: Two Molecular Sieves with Intersecting 10- and 12-Ring Pores, pp. 1543-1546
Raul F. Lobo; Ming Pan; Ignatius Chan; Hong-Xin Li; Ronald C. Medrud; Stacey I. Zones; Peter A. Crozier; Mark E. Davis
Engineered Biosynthesis of Novel Polyketides, pp. 1546-1550
Robert McDaniel; Susanne Ebert-Khosla; David A. Hopwood; Chaitan Khosla
A Binary Source Model for Extension-Related Magmatism in the Great Basin, Western North America, pp. 1550-1554
William P. Leeman; Dennis L. Harry
High-Tc Molecular-Based Magnets: Ferrimagnetic Mixed-Valence Chromium(III)-Chromium(II) Cyanides with Tc at 240 and 190 Kelvin, pp. 1554-1557
T. Mallah; S. Thiébaut; M. Verdaguer; P. Veillet
Binding to DNA and the Retinoblastoma Gene Product Promoted by Complex Formation of Different E2F Family Members, pp. 1557-1560
Wilhelm Krek; David M. Livingston; Suman Shirodkar
Visualization of Single Molecules of RNA Polymerase Sliding along DNA, pp. 1561-1563
Hiroyuki Kabata; Osamu Kurosawa; Ichiro Arai; Masao Washizu; Stefanie A. Margarson; Robert E. Glass; Nobuo Shimamoto
Nucleosome Disruption by Transcription Factor Binding in Yeast, pp. 1563-1566
Randall H. Morse
Tethering Ribozymes to a Retroviral Packaging Signal for Destruction of Viral RNA, pp. 1566-1569
Bruce A. Sullenger; Thomas R. Cech
Activation of Exocytosis by the Heterotrimeric G Protein G i3, pp. 1569-1572
Meir Aridor; Gladys Rajmilevich; Michael A. Beaven; Ronit Sagi-Eisenberg
A Link Between Cyclin A Expression and Adhesion-Dependent Cell Cycle Progression, pp. 1572-1575
Thomas M. Guadagno; Motoaki Ohtsubo; James M. Roberts; Richard K. Assoian
Characterization of a Pathway for Ciliary Neurotrophic Factor Signaling to the Nucleus, pp. 1575-1579
Azad Bonni; David A. Frank; Chris Schindler; Michael E. Greenberg
Involvement of Platelet-Endothelial Cell Adhesion Molecule-1 in Neutrophil Recruitment in Vivo, pp. 1580-1582
Ara A. Vaporciyan; Horace M. DeLisser; Horng-Chin Yan; Ignacio I. Mendiguren; Stephen R. Thom; Michael L. Jones; Peter A. Ward; Steven M. Albelda


Technical Comments
T Cell Receptor Specificity and Diabetes in Nonobese Diabetic Mice, pp. 1582-1584
Suhha Zhang; Albert Bendelac; Diane Mathis; Christophe Benoist; Myra A. Lipes; Anthony Rosenzweig; Kut-Nie Tan; Gary Tanigawa; Jonathan G. Seidman; George S. Eisenbarth
Effect of Platelet-Associated Virus on Assays of HIV-1 in Plasma, pp. 1585-1586
Tzong-Hae Lee; Robert R. Stromberg; Denis Henrard; Michael P. Busch; Michael Piatak Jr.; George M. Shaw; Limei C. Yang; John C. Kappes; Michael S. Saag; Jeffrey D. Lifson


Book Reviews
Ondelettes, pp. 1589-1591
Wavelets and Operators.
Yves Meyer
Wavelets. Algorithms and Applications.
Yves Meyer
Review author[s]: Ingrid Daubechies
Cell-Mediated Immunity, p. 1591
Viruses and the Cellular Immune Response.
D. Brian Thomas
Review author[s]: Francis Ennis
Life and Computers, pp. 1591-1592
Artificial Intelligence and Molecular Biology.
Lawrence Hunter
Review author[s]: Chris Fields
Books Received, pp. 1592-1593


Back Matter (23 pp.)

Previous Issue: New Series, Vol. 262, No. 5138, Nov. 26, 1993
Next Issue: New Series, Vol. 262, No. 5140, Dec. 10, 1993



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