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Science, New Series, Vol. 254, No. 5035, Nov. 22, 1991


Previous Issue: New Series, Vol. 254, No. 5034, Nov. 15, 1991
Next Issue: New Series, Vol. 254, No. 5036, Nov. 29, 1991


Front Matter (40 pp.)
Cancer Research: Prevention and Therapy, p. 1089
Daniel E. Koshland, Jr.


Letters
Hood Lab Investigation, pp. 1090-1091
Vipin Kumar; Eli E. Sercarz; Joseph Bressler; John Laterra


ScienceScope, p. 1099
Richard Stone


News and Comment
Weapons Labs: After the Cold War, pp. 1100-1103
Eliot Marshall
Now Dingell Probes the Academy!, p. 1103
Jon Cohen
OSTP to Wade Into Gene Patent Quagmire, pp. 1104-1105
Leslie Roberts
FDA Committee Raises AIDS Vaccine Hurdles, p. 1105
Jon Cohen
In Search of a New Cosmic Blueprint, pp. 1106-1108
Faye Flam
Neuroscience Meets in the Big Easy, pp. 1108-1109
Marcia Barinaga
Galileo Hits Its Target, p. 1109
Richard A. Kerr
Did a Rain of Comets Nurture Life?, pp. 1110-1111
Joseph Marcus
A Layer by Layer Look at the Skin Blister Diseases, pp. 1111-1112
Michelle Hoffman


Briefings
Single-Celled Killer in Monterey Bay, p. 1113
Richard Stone
Rx for Speedy Drug Approval, p. 1113
Richard Stone
A Big Chill Grips Geothermal Energy, p. 1113
Richard Stone
Tracking the AIDS Drugs, p. 1113
Richard Stone


Research News
Europe: As Many Cancers as Cuisines, pp. 1114-1115
Michael Balter
Three Europeans Find Their Own Road to Fame, pp. 1116-1117
M.B.; A.A.
Funding in Europe: How the Big Three Cope, p. 1118
Alun Anderson
Jacques Crozemarie: One Man and His Foundation, p. 1119
Michael Balter


Articles on Cancer
Toward the Primary Prevention of Cancer, pp. 1131-1138
Brian E. Henderson; Ronald K. Ross; Malcolm C. Pike
Tumor Suppressor Genes, pp. 1138-1146
Robert A. Weinberg
Growth Factors and Cancer, pp. 1146-1153
Stuart A. Aaronson
Chromosome Aberrations and Cancer, pp. 1153-1160
Ellen Solomon; Julian Borrow; Audrey D. Goddard
Transgenic Models of Tumor Development, pp. 1161-1167
Jerry M. Adams; Suzanne Cory
Viruses in Human Cancers, pp. 1167-1173
Harald zur Hausen
Recombinant Toxins for Cancer Treatment, pp. 1173-1177
Ira Pastan; David FitzGerald


Reports
Optical Coherence Tomography, pp. 1178-1181
David Huang; Eric A. Swanson; Charles P. Lin; Joel S. Schuman; William G. Stinson; Warren Chang; Michael R. Hee; Thomas Flotte; Kenton Gregory; Carmen A. Puliafito; James G. Fujimoto
Cooperative Solution of Constraint Satisfaction Problems, pp. 1181-1183
Scott H. Clearwater; Bernardo A. Huberman; Tad Hogg
Radical Reactions of C 60, pp. 1183-1185
P. J. Krusic; E. Wasserman; P. N. Keizer; J. R. Morton; K. F. Preston
Systematic Inflation of Buckminsterfullerene C 60 : Synthesis of Diphenyl Fulleroids C 61 to C 66, pp. 1186-1188
T. Suzuki; Q. Li; K. C. Khemani; F. Wudl; Ö. Almarsson
Evidence for Multiple Sources of Diamond from Primitive Chondrites, pp. 1188-1191
S. S. Russell; J. W. Arden; C. T. Pillinger
Reduced Antarctic Ozone Depletions in a Model with Hydrocarbon Injections, pp. 1191-1194
R. J. Cicerone; Scott Elliott; R. P. Turco
Transgenic Plants with Enhanced Resistance to the Fungal Pathogen Rhizoctonia solani, pp. 1194-1197
Karen Broglie; Ilan Chet; Mark Holliday; Robert Cressman; Phyllis Biddle; Susan Knowlton; C. Jeffry Mauvais; Richard Broglie
Binding of ARF and β-COP to Golgi Membranes: Possible Regulation by a Trimeric G Protein, pp. 1197-1199
Julie G. Donaldson; Richard A. Kahn; Jennifer Lippincott-Schwartz; Richard D. Klausner
Structurally Homologous Ligand Binding of Integrin Mac-1 and Viral Glycoprotein C Receptors, pp. 1200-1202
Dario C. Altieri; Orli R. Etingin; Daryl S. Fair; Terence K. Brunck; John E. Geltosky; David P. Hajjar; Thomas S. Edgington
Epidermolysis Bullosa Simplex: Evidence in Two Families for Keratin Gene Abnormalities, pp. 1202-1205
J. M. Bonifas; A. L. Rothman; E. H. Epstein, Jr.
Functional Importance of Sequence in the Stem-Loop of a Transcription Terminator, pp. 1205-1207
Sheau-Wei C. Cheng; Eileen C. Lynch; Kenneth R. Leason; Donald L. Court; Bruce A. Shapiro; David I. Friedman
Hypotensive Activity of Fibroblast Growth Factor, pp. 1208-1210
Pedro Cuevas; Fernando Carceller; Sagrario Ortega; Mercedes Zazo; Ignacio Nieto; Guillermo Giménez-Gallego
DNA Bending by Fos and Jun: The Flexible Hinge Model, pp. 1210-1214
Tom K. Kerppola; Tom Curran
Genetic Mosaics in Strangler Fig Trees: Implications for Tropical Conservation, pp. 1214-1216
James D. Thomson; E. A. Herre; J. L. Hamrick; J. L. Stone


Inside AAAS, pp. 1229-1230
Cynthia Lollar


Book Reviews
Boons to Science, pp. 1233-1234
Partners in Science. Foundations and Natural Scientists, 1900-1945.
Robert E. Kohler
Review author[s]: Larry Owens
A Center for Science, pp. 1234-1235
Millikan's School. A History of the California Institute of Technology.
Judith R. Goodstein
Review author[s]: Tony Rothman
Condensed Matter Theories, pp. 1235-1236
Field Theories of Condensed Matter Systems.
Eduardo Fradkin
Review author[s]: Robert Joynt
----------------, p. 1236
Hans Albert Einstein. Reminiscences of His Life and Our Life Together.
Elizabeth Roboz Einstein
Review author[s]: David C. Cassidy
----------------, p. 1236
Resonances. A Volume in Honor of the 70th Birthday of Nicolaas Bloembergen.
M. D. Levenson; E. Mazur; P. S. Pershan; Y. R. Shen
Review author[s]: Katherine Livingston
Books Received, pp. 1236-1237


Back Matter (31 pp.)

Previous Issue: New Series, Vol. 254, No. 5034, Nov. 15, 1991
Next Issue: New Series, Vol. 254, No. 5036, Nov. 29, 1991



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