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Previous Issue: New Series, Vol. 277, No. 5334, Sep. 26, 1997
Next Issue: New Series, Vol. 278, No. 5336, Oct. 10, 1997
Front Matter (31 pp.)
Editorial: The Science of Substance Abuse, p. 15
- Floyd E. Bloom
Letters
- Top Talent at NSF, p. 17
- Mary Hanson
- Ring Laser Design, p. 17
- H. R. Bilger
- Analogies with Meaning, p. 18
- Robert Goldberg
- NASA Funding for Earth Science, pp. 18-19
- Robert Harriss
- Polio Vaccine Production, p. 19
- Stanley A. Plotkin
- Clean Air Skepticism, pp. 19-20
- Frederick W. Lipfert
- Genetic Evolution of Morphology, pp. 20-21
- Stuart A. Newman
- Resonance Raman Results: Retraction, p. 21
- Thomas G. Spiro
Corrections and Clarifications: Telomerase Activity of Reverse Transcriptase, p. 21
Corrections and Clarifications: Human Domination of Earth's Ecosystems, p. 21
Corrections and Clarifications: Epilepsy and Exacerbation of Brain Injury in Mice Lacking the Glutamate Transporter GLT-1, p. 21
ScienceScope, p. 23
- Jocelyn Kaiser
News
- Weakened SIV Vaccine Still Kills, pp. 24-25
- Jon Cohen
- Berkeley Facility Ranks Low On Advisory Panel's List, pp. 25-26
- Andrew Lawler
- Furor Over Company Deal Roils AMA, p. 26
- Jocelyn Kaiser
- Stanford Researcher Fights Dismissal in Hospital Spat, p. 27
- Constance Holden
- Government Bows Out of Academy Case, p. 28
- Andrew Lawler
- Scandal Claims Science Minister, p. 28
- Elizabeth Finkel
- JET Takes a Step Closer to Break-Even, p. 29
- Alexander Hellemans
- Staff Makes Bid to Privatize Observatory, pp. 29-30
- Nigel Williams
- Friendly Finish Looms on Spending, p. 30
- Andrew Lawler
- Socialists Reverse Budget Decline, p. 31
- Michael Balter
- New Studies Affirm BSE-Human Link, p. 31
- Nigel Williams
- Near the Lights of Vegas, Chemists Are on a Roll, pp. 32-33
- Robert F. Service
- Olefin Catalyst Keeps Things Short, pp. 33-34
- Robert F. Service
- Males Mutate More, Bird Study Shows, p. 34
- Steven Dickman
Special News Report
- Getting the Brain's Attention, pp. 35-37
- Ingrid Wickelgren
- Cocaine Wreaks Subtle Damage on Developing Brains, pp. 38-39
- Gretchen Vogel
Random Samples, p. 41
- Constance Holden
Frontiers in Neuroscience: The Science of Substance Abuse
- Addiction is a Brain Disease, and it Matters, pp. 45-47
- Alan I. Leshner
- Interpreting Dutch Cannabis Policy: Reasoning by Analogy in the Legalization Debate, pp. 47-52
- Robert MacCoun; Peter Reuter
- Drug Abuse: Hedonic Homeostatic Dysregulation, pp. 52-58
- George F. Koob; Michel Le Moal
- Molecular and Cellular Basis of Addiction, pp. 58-63
- Eric J. Nestler; George K. Aghajanian
- Psychoactive Drug Use in Evolutionary Perspective, pp. 63-66
- Randolph M. Nesse; Kent C. Berridge
- A Range of Research-Based Pharmacotherapies for Addiction, pp. 66-70
- Charles P. O'Brien
Book Reviews
- An Ongoing Debate, p. 75
- Marijuana Myths, Marijuana Fact. A Review of the Scientific Evidence.
- Lynn Zimmer; John P. Morgan
- Review author[s]: Wayne Hall
- Also Noteworthy, p. 75
- Dugs of Abuse.
- Simon Wills
Perspectives
- Chondrites and the Solar Nebula, pp. 76-77
- Adrian Brearley
- Carbon Nanotubes for Next-Generation Electronics Devices, pp. 77-78
- Susumu Saito
- MutT Prevents Leakiness, pp. 78-79
- Bryn A. Bridges
- Unconscious Odors, p. 79
- Pamela J. Hines
- Proteins from Scratch, pp. 80-81
- William F. DeGrado
Webwatch, p. 81
- David Voss
Research Article
- De Novo Protein Design: Fully Automated Sequence Selection, pp. 82-87
- Bassil I. Dahiyat; Stephen L. Mayo
Reports
- Accretion Rates of Meteorites and Cosmic Dust in the Early Ordovician, pp. 88-90
- Birger Schmitz; Bernhard Peucker-Ehrenbrink; Maurits Lindström; Mario Tassinari
- Measurements of 12 C/ 13 C, 14 N/ 15 N, and 32 S/ 34 S Ratios in Comet Hale-Bopp (C/1995 01), pp. 90-93
- David C. Jewitt; Henry E. Matthews; Tobias Owen; Roland Meier
- Midwinter Start to Antarctic Ozone Depletion: Evidence from Observations and Models, pp. 93-96
- H. K. Roscoe; A. E. Jones; A. M. Lee
- Time-Domain Holographic Digital Memory, pp. 96-100
- Xiao A. Shen; An-Dien Nguyen; John W. Perry; David L. Huestis; Ravinder Kachru
- Nanotube Nanodevice, pp. 100-103
- Philip G. Collins; A. Zettl; Hiroshi Bando; Andreas Thess; R. E. Smalley
- Ste5 RING-H2 Domain: Role in Ste4-Promoted Oligomerization for Yeast Pheromone Signaling, pp. 103-106
- Carla Inouye; Namrita Dhillon; Jeremy Thorner
- Negative Regulation by HLA-DO of MHC Class II-Restricted Antigen Processing, pp. 106-109
- Lisa K. Denzin; Derek B. Sant'Angelo; Craig Hammond; Michael J. Surman; Peter Cresswell
- Interdomain Interactions Underlying Activation of Cyclic Nucleotide-Gated Channels, pp. 110-113
- Michael D. Varnum; William N. Zagotta
- Mediation of Neuronal Apoptosis by Enhancement of Outward Potassium Current, pp. 114-117
- Shan Ping Yu; Chen-Hsiung Yeh; Stefano L. Sensi; Byoung J. Gwag; Lorella M. T. Canzoniero; Z. Shadi Farhangrazi; Howard S. Ying; Min Tian; Laura L. Dugan; Dennis W. Choi
- Immunotherapy of Tumors with Autologous Tumor-Derived Heat Shock Protein Preparations, pp. 117-120
- Yasuaki Tamura; Ping Peng; Kang Liu; Maria Daou; Pramod K. Srivastava
- Rapid Colorectal Adenoma Formation Initiated by Conditional Targeting of the Apc Gene, pp. 120-123
- Hiroyuki Shibata; Kaoru Toyama; Hisashi Shioya; Masaki Ito; Morihisa Hirota; Sumitaka Hasegawa; Hiroshi Matsumoto; Hiroshi Takano; Tetsu Akiyama; Kumao Toyoshima; Ryunosuke Kanamaru; Yumi Kanegae; Izumu Saito; Yusuke Nakamura; Kiyotaka Shiba; Tetsuo Noda
- Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap 1, pp. 124-128
- Vassiliki A. Boussiotis; Gordon J. Freeman; Alla Berezovskaya; Dwayne L. Barber; Lee M. Nadler
- Counteraction by MutT Protein of Transcriptional Errors Caused by Oxidative Damage, pp. 128-130
- F. Taddei; H. Hayakawa; M.-F. Bouton; A.-M. Cirinesi; I. Matic; M. Sekiguchi; M. Radman
- Functional Dynamics of GABAergic Inhibition in the Thalamus, pp. 130-134
- Uhnoh Kim; Maria V. Sanchez-Vives; David A. McCormick
- Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein, pp. 135-138
- Michael M. Ollmann; Brent D. Wilson; Ying-Kui Yang; Julie A. Kerns; Yanru Chen; Ira Gantz; Gregory S. Barsh
- NF-AT Activation Induced by a CAML-Interacting Member of the Tumor Necrosis Factor Receptor Superfamily, pp. 138-141
- Götz-Ulrich von Bülow; Richard J. Bram
- Evidence for a Role of CRM1 in Signal-Mediated Nuclear Protein Export, pp. 141-144
- Batool Ossareh-Nazari; Françoise Bachelerie; Catherine Dargemont
Technical Comments
- The Possibility of Ice on the Moon, pp. 144-145
- S. J. Weidenschilling; S. Nozette; E. M. Shoemaker; P. Spudis; C. L. Lichtenberg; N. J. S. Stacy; D. B. Campbell; P. G. Ford
Science's Next Wave: Work in Clinical Research- Without a Medical Degree, p. 153
- Nicole Ruediger
Back Matter (35 pp.)
Previous Issue: New Series, Vol. 277, No. 5334, Sep. 26, 1997
Next Issue: New Series, Vol. 278, No. 5336, Oct. 10, 1997