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Science, New Series, Vol. 249, No. 4968, Aug. 3, 1990


Previous Issue: New Series, Vol. 249, No. 4967, Jul. 27, 1990
Next Issue: New Series, Vol. 249, No. 4969, Aug. 10, 1990


Front Matter (18 pp.)
Dialog on the Future of Agriculture, p. 457
Philip H. Abelson


Letters
Cold Fusion at Texas A&M, pp. 463-465
Duwayne M. Anderson; J. O'M. Bockris; D. H. Worledge; Gary Taubes
Viral Etiology of AIDS and the Gallo Probe, pp. 465-466
Albert B. Sabin; Jack W. Shields


Erratum: The Untold Story of HUT78, p. 466
Erratum: Birds under Selection (1 p.)


News and Comment
Oregon Puts Bold Health Plan on Ice, pp. 468-471
Virginia Morell
Oregon's Plan Comes to the Capital, p. 469
David P. Hamilton
NIH Sued Over Misconduct Case, p. 471
David P. Hamilton
A Base Dispute, pp. 472-473
M. Mitchell Waldrop
SSC Cost Estimates Climb, p. 473
Mark Crawford
Radiation Exposure: Hot Legacy of the Cold War, p. 474
Eliot Marshall


Briefings
Bick Replacement Named, p. 475
Constance Holden
Yet Another Job for Wyngaarden, p. 475
Constance Holden
Chinese Still Coming, p. 475
Constance Holden
Doing Science at the Gates of Hell, p. 475
Constance Holden


Research News
Meta-Analysis in the Breech, pp. 476-480
Charles Mann
New Greenhouse Report Puts Down Dissenters, pp. 481-482
Richard A. Kerr
New Clue to Cancer Metastasis Found, pp. 482-483
Jean Marx


Perspectives
Directed Evolution of Nucleic Acids by Independent Replication and Selection, pp. 488-489
John Abelson
Telomeres and Their Synthesis, pp. 489-490
Elizabeth H. Blackburn


From Force Fields to Dynamics: Classical and Quantal Paths, pp. 491-498
Donald G. Truhlar; Mark S. Gordon

Chaos Versus Noisy Periodicity: Alternative Hypotheses for Childhood Epidemics, pp. 499-504
L. F. Olsen; W. M. Schaffer


Research Articles
Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase, pp. 505-510
Craig Tuerk; Larry Gold
The Hin Invertasome: Protein-Mediated Joining of Distant Recombination Sites at the Enhancer, pp. 511-517
Karen A. Heichman; Reid C. Johnson


Reports
Structural Transitions upon Ligand Binding in a Cooperative Dimeric Hemoglobin, pp. 518-521
William E. Royer, Jr.; Wayne A. Hendrickson; Emilia Chiancone
Molecular Structure of Charybdotoxin, a Pore-Directed Inhibitor of Potassium Ion Channels, pp. 521-524
Walter Massefski, Jr.; Alfred G. Redfield; Dennis R. Hare; Christopher Miller
The Energetic Cost of Limbless Locomotion, pp. 524-527
Michael Walton; Bruce C. Jayne; Albert F. Bennett
Design, Activity, and 2.8 A Crystal Structure of a C2 Symmetric Inhibitor Complexed to HIV-1 Protease, pp. 527-533
John Erickson; David J. Neidhart; John VanDrie; Dale J. Kempf; Xiu Chun Wang; Daniel W. Norbeck; Jacob J. Plattner; Judith W. Rittenhouse; Mary Turon; Norman Wideburg; William E. Kohlbrenner; Robert Simmer; Rosalind Helfrich; Deborah A. Paul; Mark Knigge
Identification of a Sequence in the PEPCK Gene That Mediates a Negative Effect of Insulin on Transcription, pp. 533-537
Richard M. O'Brien; Peter C. Lucas; Claude D. Forest; Mark A. Magnuson; Daryl K. Granner
Protection Against Mucoid Pseudomonas aeruginosa in Rodent Models of Endobronchial Infections, pp. 537-540
Gerald B. Pier; Gloria J. Small; Henry B. Warren
Regulation of Activity of a Transcriptional Anti-Terminator in E. coli by Phosphorylation in Vivo, pp. 540-542
Orna Amster-Choder; Andrew Wright
Crystal Structure of α1: Implications for Protein Design, pp. 543-546
Christopher P. Hill; Daniel H. Anderson; Laura Wesson; William F. DeGrado; David Eisenberg
Antibody-Mediated Activation of Drosophila Heat Shock Factor in Vitro, pp. 546-549
Vincenzo Zimarino; Susan Wilson; Carl Wu
Specific Tropism of HIV-1 for Microglial Cells in Primary Human Brain Cultures, pp. 549-553
Brynmor A. Watkins; Henry H. Dorn; Walter B. Kelly; Regina C. Armstrong; Barbara J. Potts; Frank Michaels; Conrad V. Kufta; Monique Dubois-Dalcq
Protein Tyrosine Phosphatase Activity of an Essential Virulence Determinant in Yersinia, pp. 553-556
Kunliang Guan; Jack E. Dixon
A Family of AMPA-Selective Glutamate Receptors, pp. 556-560
Kari Keinänen; William Wisden; Bernd Sommer; Pia Werner; Anne Herb; Todd A. Verdoorn; Bert Sakmann; Peter H. Seeburg
A Mouse Macrophage Factor Induces Head Structures and Organizes a Body Axis in Xenopus, pp. 561-564
S. Sokol; G. G. Wong; D. A. Melton


Technical Comments
Binocular Depth Reversals Despite Familiarity Cues: An Artifact?, pp. 565-566
J. A. Deutsch; V. S. Ramachandran; Eli Peli; Aad van den Enden; Henk Spekreijse
HIP-70: An Isoform of Phosphoinositol-Specific Phospholipase C-α, pp. 566-567
Charles V. Mobbs; George Fink; Donald W. Pfaff; Winona C. Barker; Lois T. Hunt; John C. M. Tsibris; William N. Spellacy


Inside AAAS, pp. 568-569


Book Reviews
Constraints in the Third Reich, p. 570
German National Socialism and the Quest for Nuclear Power, 1939-1949.
Mark Walker
Review author[s]: Peter Hayes
Lives, pp. 571-572
Recollections of My Life.
Santiago Ramón y Cajal
The Never-Ceasing Search.
Francis O. Schmitt
Song Among the Ruins.
William J. Schull
Science, Churchill, and Me.
Herman Bondi
A Very Decided Preference. Life with Peter Medawar.
Jean Medawar
Landau. The Physicist and the Man.
I. M. Khalatnikov
Chandrasekhara Venkata Raman.
A. Jayaraman
Review author[s]: Katherine Livingston
Metrology in Physics, p. 572
The Art of Measurement. Metrology in Fundamental and Applied Physics.
Bernhard Kramer
Review author[s]: Rogers C. Ritter
Heat Shock, pp. 572-573
Stress Proteins in Biology and Medicine.
Richard I. Morimoto; Alfred Tissières; Costa Georgopoulos
Review author[s]: Lawrence E. Hightower
Books Received, pp. 573-574


Back Matter (22 pp.)

Previous Issue: New Series, Vol. 249, No. 4967, Jul. 27, 1990
Next Issue: New Series, Vol. 249, No. 4969, Aug. 10, 1990



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