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Science, New Series, Vol. 245, No. 4916, Jul. 28, 1989


Previous Issue: New Series, Vol. 245, No. 4915, Jul. 21, 1989
Next Issue: New Series, Vol. 245, No. 4917, Aug. 4, 1989


Front Matter (9 pp.)


Policy Forum
Project 2061: A Congressional View, p. 340
George E. Brown


The Underrepresentation Syndrome, p. 341
Daniel E. Koshland


Letters
Genome Analysis, p. 342
Daniel B. Davison
Attending to Inattention, p. 342
David F. Dinges; R. Curtis Graeber; Mary A. Carskadon; Charles A. Czeisler; William C. Dement
Correction: RuGli Cell Line not of Human Origin, pp. 342-343
Kurt Gehlsen; Eva Engvall; Lena Dillner; Erkki Ruoslahti; Simon Goodman


Erratum: Genome Planners Fear Avalanche of Red Tape, p. 343
Erratum: Activation of Salivary Secretion: Coupling of Cell Volume and [Ca 2+ ] in Single Cells, p. 343


Perspective
T Cell Signaling, p. 344
Roger M. Perlmutter


News & Comment
Quick Release of AIDS Drugs, pp. 345+347
Eliot Marshall
Drug Availability is an Issue for Cancer Patients, Too, pp. 346-347
Jean L. Marx
Soviet Psychiatry: Real Progress or Just PR?, p. 348
Constance Holden
Senate Committee Quizzes Bromley, p. 349
Mark Crawford
New round in Dingell v. NIH?, p. 349
Joseph Palca
Zs For Two: A Critical Mass, p. 350
M. Mitchell Waldrop
Gallo Associate Subject to Investigation, p. 350
C.H.
Headed for NOAA's Choppy Waters, p. 350
R.A.K.


Research News
Sleep Researchers Awake to Possibilities, pp. 351-352
Joseph Palca
New AIDS Drug Passes First Clinical Test, p. 353
Jean L. Marx
``Chemzymes'' Mimic Biology in Miniature, pp. 354-355
M. Mitchell Waldrop
DNA Typing is Called Flawed, p. 355
Roger Lewin


The Bitter Pill, pp. 356-361
Carl Djerassi

Computational Aerodynamics for Aircraft Design, pp. 361-371
Antony Jameson

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins, pp. 371-378
Pamela J. Mitchell; Robert Tjian

Genetic and Pharmacological Suppression of Oncogenic Mutations in RAS Genes of Yeast and Humans, pp. 379-385
William R. Schafer; Rosalind Kim; Rachel Sterne; Jeremy Thorner; Sung-Hou Kim; Jasper Rine

Peptide Binding and Release by Proteins Implicated as Catalysts of Protein Assembly, pp. 385-390
Gregory C. Flynn; Thomas G. Chappell; James E. Rothman


Reports
GaAs Clusters in the Quantum Size Regime: Growth on High Surface Area Silica by Molecular Beam Epitaxy, pp. 391-393
C. J. Sandroff; J. P. Harbison; R. Ramesh; M. J. Andrejco; M. S. Hegde; D. M. Hwang; C. C. Chang; E. M. Vogel
Experiments on Hydraulic Jumps in Turbidity Currents near a Canyon-Fan Transition, pp. 393-396
Marcelo Garcia; Gary Parker
Understanding the Anomalous Electrophoresis of Bent DNA Molecules: A Reptation Model, pp. 396-399
Stephen D. Levene; Bruno H. Zimm
Lignin-Like Compounds and Sporopollenin in Coleochaete, an Algal Model for Land Plant Ancestry, pp. 399-401
Charles F. Delwiche; Linda E. Graham; Norman Thomson
Activation of Apical Chloride Channels in the Gastric Oxyntic Cell, pp. 402-404
Jeffery R. Demarest; Donald D. F. Loo; George Sachs
The Location of DNA in RecA-DNA Helical Filaments, pp. 404-407
E. H. Egelman; X. Yu
Activators of Protein Kinase C Induce Dissociation of CD4, but not CD8, from p56 lck, pp. 407-409
Tamara R. Hurley; Kunxin Luo; Bartholomew M. Sefton
Recombinant 47-Kilodalton Cytosol Factor Restores NADPH Oxidase in Chronic Granulomatous Disease, pp. 409-412
Karen J. Lomax; Thomas L. Leto; Hiroyuki Nunoi; John I. Gallin; Harry L. Malech
In vivo Activity against HIV and Favorable Toxicity Profile of 2 ,3 -Dideoxyinosine, pp. 412-415
Robert Yarchoan; Hiroaki Mitsuya; Rose V. Thomas; James M. Pluda; Neil R. Hartman; Carlo-Federico Perno; Kathy S. Marczyk; Jean-Pierre Allain; David G. Johns; Samuel Broder
Brain Region and Gene Specificity of Neuropeptide Gene Expression in Cultured Astrocytes, pp. 415-417
Hisaharu Shinoda; Ann M. Marini; Cristina Cosi; Joan P. Schwartz
Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease, pp. 417-420
Bruce A. Yankner; Linda R. Dawes; Shannon Fisher; Lydia Villa-Komaroff; Mary Lou Oster-Granite; Rachael L. Neve


Book Reviews
Sexuality: Reports from 1970, pp. 421-422
Sex and Morality in the U.S
Albert D. Klassen; Colin J. Williams; Eugene E. Levitt; Hubert J. O'Gorman
Review author[s]: John DeLamater
Colonial Adaptations, p. 422
Bryozoan Evolution
F. K. McKinney; J. B. C. Jackson
Review author[s]: Russel L. Zimmer
Rifted Margins, pp. 423-424
Early Tertiary Volcanism and the Opening of the NE Atlantic
A. C. Morton; L. M. Parson
Review author[s]: Jeffrey Karson
Some Other Books of Interest, p. 424
Global Volcanism 1975-1985
Lindsay McClelland; Tom Simkin; Marjorie Summers; Elizabeth Nielsen; Thomas C. Stein
Radioactivity and Health
J. Newell Stannard
Review author[s]: K.L.


Back Matter (17 pp.)

Previous Issue: New Series, Vol. 245, No. 4915, Jul. 21, 1989
Next Issue: New Series, Vol. 245, No. 4917, Aug. 4, 1989



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