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Science, New Series, Vol. 259, No. 5102, Mar. 19, 1993


Previous Issue: New Series, Vol. 259, No. 5101, Mar. 12, 1993
Next Issue: New Series, Vol. 259, No. 5103, Mar. 26, 1993


Front Matter (13 pp.)
Editorial: Expanding the Uses of Enzymes, p. 1675
Philip H. Abelson


Letters
The Oberrothenbach Catastrophe, pp. 1676-1677
Lee W. Wattenberg; Robert N. Proctor
Contamination of cDNA Sequences in Databases, pp. 1677-1678
Charalambos Savakis; Reinhard Doelz
Biotechnology in Japan, p. 1678
Henry I. Miller
Gene Therapy Approval Process, pp. 1678-1679
Ivor Royston
The Cost of Regulation, p. 1679
Thomas D. Hopkins
From the Vatican, p. 1679
G. B. Marini-Bettòlo


ScienceScope, p. 1683
Richard Stone


News and Comment
Genome Shortcut Leads to Problems, pp. 1684-1687
Christopher Anderson
NASA Puts the Squeeze on the Station, p. 1687
Faye Flam
Can Basic Research Ever Find A Good Home in Biosphere 2?, pp. 1688-1689
Traci Watson
Controversial Vaccine Shows Promise, pp. 1689-1690
John Maurice
Swords-to-Plowshares Plan Boosts R&D, p. 1690
Eliot Marshall


Research News
Naked DNA Points Way to Vaccines, pp. 1691-1692
Jon Cohen
Could Quasars Get Their Shine From Stars?, pp. 1692-1693
Ray Jayawardhana
Interfering With Interferon, pp. 1693-1694
Marcia Barinaga
Ecologists Put Some Life Into Models of a Changing World, pp. 1694-1696
Yvonne Baskin
More Venus Science, or The Off Switch for Magellan?, pp. 1696-1697
Richard A. Kerr


Random Samples, pp. 1698-1699
Ivan Amato


Perspectives
The Carved Stela from La Mojarra, Veracruz, Mexico, pp. 1700-1701
George E. Stuart
Does E. coli Have a Nose?, pp. 1701-1702
John S. Parkinson; David F. Blair


A Decipherment of Epi-Olmec Hieroglyphic Writing, pp. 1703-1711
John S. Justeson; Terrence Kaufman

Ancient Conserved Regions in New Gene Sequences and the Protein Databases, pp. 1711-1716
Philip Green; David Lipman; LaDeana Hillier; Robert Waterston; David States; Jean-Michel Claverie


Research Article
Polar Location of the Chemoreceptor Complex in the Escherichia coli Cell, pp. 1717-1723
Janine R. Maddock; Lucille Shapiro


Reports
Formation of Nanometer-Scale Grooves in Silicon with a Scanning Tunneling Microscope, pp. 1724-1726
A. Kobayashi; F. Grey; R. S. Williams; M. Aono
Boundary Layer Profiles in Plasma Chemical Vapor Deposition, pp. 1726-1729
David S. Green; Thomas G. Owano; Skip Williams; David G. Goodwin; Richard N. Zare; Charles H. Kruger
Cryptic Grain-Scale Heterogeneity of Oxygen Isotope Ratios in Metamorphic Magnetite, pp. 1729-1733
John W. Valley; Colin M. Graham
The 18 O/ 16 O Ratio of 2-Billion-Year-Old Seawater Inferred from Ancient Oceanic Crust, pp. 1733-1736
C. Holmden; K. Muehlenbachs
Released Form of CNTF Receptor α Component as a Soluble Mediator of CNTF Responses, pp. 1736-1739
Samuel Davis; Thomas H. Aldrich; Nancy Y. Ip; Neil Stahl; Steven Scherer; Thomas Farruggella; Peter S. DiStefano; Rory Curtis; Nikos Panayotatos; Hugues Gascan; Sylvie Chevalier; George D. Yancopoulos
Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes, pp. 1739-1742
Dyana K. Dalton; Sharon Pitts-Meek; Satish Keshav; Irene S. Figari; Allan Bradley; Timothy A. Stewart
Immune Response in Mice That Lack the Interferon-γ Receptor, pp. 1742-1745
Sui Huang; Wiljan Hendriks; Alana Althage; Silvio Hemmi; Horst Bluethmann; Ryutaro Kamijo; Jan Vilček; Rolf M. Zinkernagel; Michel Aguet
Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein, pp. 1745-1749
Jeffrey B. Ulmer; John J. Donnelly; Suezanne E. Parker; Gary H. Rhodes; Philip L. Felgner; V. J. Dwarki; Stanislaw H. Gromkowski; R. Randall Deck; Corrille M. DeWitt; Arthur Friedman; Linda A. Hawe; Karen R. Leander; Douglas Martinez; Helen C. Perry; John W. Shiver; Donna L. Montgomery; Margaret A. Liu
High Levels of HIV-1 in Plasma During All Stages of Infection Determined by Competitive PCR, pp. 1749-1754
M. Piatak, Jr.; M. S. Saag; L. C. Yang; S. J. Clark; J. C. Kappes; K.-C. Luk; B. H. Hahn; G. M. Shaw; J. D. Lifson
Requirement of the Carboxyl Terminus of a Bacterial Chemoreceptor for Its Targeted Proteolysis, pp. 1754-1757
M. R. K. Alley; Janine R. Maddock; Lucille Shapiro
Microbial Competition: Escherichia coli Mutants That Take Over Stationary Phase Cultures, pp. 1757-1760
María Mercedes Zambrano; Deborah A. Siegele; Marta Almirón; Antonio Tormo; Roberto Kolter
An Osmosensing Signal Transduction Pathway in Yeast, pp. 1760-1763
Jay L. Brewster; Tamsen de Valoir; Noelle D. Dwyer; Edward Winter; Michael C. Gustin
PAC-1: A Mitogen-Induced Nuclear Protein Tyrosine Phosphatase, pp. 1763-1766
Patricia J. Rohan; Paula Davis; Christopher A. Moskaluk; Mary Kearns; Henry Krutzsch; Ulrich Siebenlist; Kathleen Kelly
Requirement for Cdk2 in Cytostatic Factor-Mediated Metaphase II Arrest, pp. 1766-1769
Brian G. Gabrielli; Linda M. Roy; James L. Maller
Programmed Cell Death Induced by Ceramide, pp. 1769-1771
Lina M. Obeid; Corinne M. Linardic; Linda A. Karolak; Yusuf A. Hannun


Technical Comments
Ambiguities in Ab Initio Phasing, pp. 1771-1772
Todd O. Yeates; Kam Y. J. Zhang; S. Subbiah


Book Reviews
Instruments of Control, pp. 1773-1774
Testing Testing. Social Consequences of the Examined Life.
F. Allan Hanson
Review author[s]: Robert Jackall
Affinities and Rationales, pp. 1774-1775
The Diversity of Life.
Edward O. Wilson
Review author[s]: Robert E. Ricklefs
Being First, pp. 1775-1776
The Cambridge Guide to Astronomical Discovery.
William Liller
Review author[s]: Ruth C. Peterson
Books Received, p. 1776


Back Matter (20 pp.)

Previous Issue: New Series, Vol. 259, No. 5101, Mar. 12, 1993
Next Issue: New Series, Vol. 259, No. 5103, Mar. 26, 1993



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