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Science, New Series, Vol. 293, No. 5532, Aug. 10, 2001


Previous Issue: New Series, Vol. 293, No. 5531, Aug. 3, 2001
Next Issue: New Series, Vol. 293, No. 5533, Aug. 17, 2001


Front Matter (27 pp.)
Editorial: Death at Johns Hopkins, p. 1013
Donald Kennedy

Editors' Choice, pp. 1015+1017
Gilbert Chin

Netwatch, p. 1019
Mitch Leslie


News


News of the Week
Hopkins Reviews Investment in Indian Cancer Drug Trial, p. 1024
Pallava Bagla; Eliot Marshall
Would Cloning Ban Affect Stem Cells?, p. 1025
Constance Holden
Academy Backs off Cold War-Style Rules, pp. 1025+1027
Andrey Allakhverdov; Vladimir Pokrovsky
A Molecular Approach to Mushroom Hunting, pp. 1027-1028
Elizabeth Pennisi
ScienceScope, pp. 1027+1029
Andrew Lawler; Richard Stone
Sand Fly Saliva May Be Key to New Vaccine, p. 1028
Martin Enserink
Ireland Gives Its Stars a Big Pot o' Gold, pp. 1028-1029
John Pickrell
Possible New Path for Blood Pressure Control, p. 1030
Jean Marx
Smooth X-Rays Fill the Milky Way's Disk, pp. 1030-1031
Robert Irion
Fall Fight Looms over Space Science Funding, pp. 1031+1033
Andrew Lawler
Mideast Pirates Give Oceanographers Pause, p. 1033
David Malakoff
RIKEN Scientist Quits; Lab Says It's Clean, p. 1033
Dennis Normile


News Focus
Building a Small-Animal Model for AIDS, Block by Block, pp. 1034-1036
Jon Cohen
Mass Extinctions Face Downsizing, Extinction, p. 1037
Richard A. Kerr
Biochemist Wages Online War against Ethical Lapses, p. 1039
Xiong Lei
Twin Stars of Astrophysics Make Room for Two, pp. 1040-1041
Mark Sincell
Random Samples, p. 1043
Constance Holden


Science's Compass


Letters
Parks and Factors in Their Success, pp. 1045-1047
Marc Stern; Shonil Bhagwat; Nick Brown; Tom Evans; Stephen Jennings; Peter Savill; A. G. Bruner; R. E. Gullison; R. E. Rice; G. A. B. da Fonseca
In Defense of Antisense, pp. 1047-1048
Richard K. Koehn; John Rossi; C. A. Stein
Lateral Gene Transfer or Viral Colonization?, p. 1048
Victor Defilippis; Luis P. Villarreal; Steven L. Salzberg; Jonathan A. Eisen

Corrections and Clarifications: Haplotype Variation and Linkage Disequilibrium in 313 Human Genes, p. 1048
Corrections and Clarifications: Evidence for Substantial Variations of Atmospheric Hydroxyl Radicals in the Past Two Decades, p. 1048
Corrections and Clarifications: Portugal: A Case History in S&T Cooperation, p. 1048


Policy Forum
Responding to Market Failures in Tuberculosis Control, pp. 1049-1051
Rajesh Gupta; Jim Y. Kim; Marcos A. Espinal; Jean-Michel Caudron; Bernard Pecoul; Paul E. Farmer; Mario C. Raviglione


Books et al.
Formative Effects of Federal Funding, pp. 1052-1053
Shaping Biology: The National Science Foundation and American Biological Research, 1945-1975
Toby Appel
Review author[s]: James E. Strick
Nota Bene: For the Curious, p. 1053
How Things Work: The Physics of Everyday Life. 2nd Ed.
Louis A. Bloomfield
Scientific American: How Things Work Today
Michael Wright; Mukul Patel
Review author[s]: Marc Lavine


Perspectives
A Paradigm for Precision, pp. 1054-1055
Kevin Struhl
Probing Matter at the Lowest Densities, pp. 1055-1056
Jordi Miralda-Escudé
The Origin of Water on Earth, pp. 1056-1058
Francois Robert
Believe It or Not: Translation in the Nucleus, pp. 1058-1059
Matthias W. Hentze
Solar Cells by Self-Assembly?, pp. 1059-1060
Jenny Nelson


Epigenetics
The Evolution of Epigenetics, p. 1063
Guy Riddihough; Elizabeth Pennisi


News
Behind the Scenes of Gene Expression, pp. 1064-1067
Elizabeth Pennisi


Viewpoints and Reviews
The Role of DNA Methylation in Mammalian Epigenetics, pp. 1068-1070
Peter A. Jones; Daiya Takai
DNA Methylation and Epigenetic Inheritance in Plants and Filamentous Fungi, pp. 1070-1074
Robert A. Martienssen; Vincent Colot
Translating the Histone Code, pp. 1074-1080
Thomas Jenuwein; C. David Allis
RNA: Guiding Gene Silencing, pp. 1080-1083
Marjori Matzke; Antonius J. M. Matzke; Jan M. Kooter
Epigenetic Aspects of X-Chromosome Dosage Compensation, pp. 1083-1085
Yongkyu Park; Mitzi I. Kuroda
Imprinting and the Epigenetic Asymmetry between Parental Genomes, pp. 1086-1089
Anne C. Ferguson-Smith; M. Azim Surani
Epigenetic Reprogramming in Mammalian Development, pp. 1089-1093
Wolf Reik; Wendy Dean; Jörn Walter
Nuclear Cloning and Epigenetic Reprogramming of the Genome, pp. 1093-1098
William M. Rideout III; Kevin Eggan; Rudolf Jaenisch
The Centromere Paradox: Stable Inheritance with Rapidly Evolving DNA, pp. 1098-1102
Steven Henikoff; Kami Ahmad; Harmit S. Malik
Genes, Genetics, and Epigenetics: A Correspondence, pp. 1103-1105
C.-t. Wu; J. R. Morris


Research


Research Article
Human Hypertension Caused by Mutations in WNK Kinases, pp. 1107-1112
Frederick H. Wilson; Sandra Disse-Nicodème; Keith A. Choate; Kazuhiko Ishikawa; Carol Nelson-Williams; Isabelle Desitter; Murat Gunel; David V. Milford; Graham W. Lipkin; Jean-Michel Achard; Morgan P. Feely; Bertrand Dussol; Yvon Berland; Robert J. Unwin; Haim Mayan; David B. Simon; Zvi Farfel; Xavier Jeunemaitre; Richard P. Lifton


Reports
Resolving the Structure of Ionized Helium in the Intergalactic Medium with the Far Ultraviolet Spectroscopic Explorer, pp. 1112-1116
G. A. Kriss; J. M. Shull; W. Oegerle; W. Zheng; A. F. Davidsen; A. Songaila; J. Tumlinson; L. L. Cowie; J.-M. Deharveng; S. D. Friedman; M. L. Giroux; R. F. Green; J. B. Hutchings; E. B. Jenkins; J. W. Kruk; H. W. Moos; D. C. Morton; K. R. Sembach; T. M. Tripp
No Supermassive Black Hole in M33?, pp. 1116-1118
David Merritt; Laura Ferrarese; Charles L. Joseph
Self-Organized Discotic Liquid Crystals for High-Efficiency Organic Photovoltaics, pp. 1119-1122
L. Schmidt-Mende; A. Fechtenkötter; K. Müllen; E. Moons; R. H. Friend; J. D. MacKenzie
Polarization Mode Control of Two-Dimensional Photonic Crystal Laser by Unit Cell Structure Design, pp. 1123-1125
Susumu Noda; Mitsuru Yokoyama; Masahiro Imada; Alongkarn Chutinan; Masamitsu Mochizuki
High-Temperature Ferromagnetism in CaB2C2</latex>, pp. 1125-1127
J. Akimitsu; K. Takenawa; K. Suzuki; H. Harima; Y. Kuramoto
Runaway Growth of Planetary Embryos Facilitated by Massive Bodies in a Protoplanetary Disk, pp. 1127-1129
Stephen J. Kortenkamp; George W. Wetherill; Satoshi Inaba
Molecular Evidence for the Early Colonization of Land by Fungi and Plants, pp. 1129-1133
Daniel S. Heckman; David M. Geiser; Brooke R. Eidell; Rebecca L. Stauffer; Natalie L. Kardos; S. Blair Hedges
Coordination of a Transcriptional Switch by HMGI(Y) Acetylation, pp. 1133-1136
Nikhil Munshi; Theodora Agalioti; Stavros Lomvardas; Menie Merika; Guoying Chen; Dimitris Thanos
Cytokine-Specific Transcriptional Regulation through an IL-5Rα Interacting Protein, pp. 1136-1138
Niels Geijsen; Iain J. Uings; Cornelieke Pals; John Armstrong; Murray McKinnon; Jan A. M. Raaijmakers; Jan-Willem J. Lammers; Leo Koenderman; Paul J. Coffer
Coupled Transcription and Translation within Nuclei of Mammalian Cells, pp. 1139-1142
Francisco J. Iborra; Dean A. Jackson; Peter R. Cook
Snf1: A Histone Kinase That Works in Concert with the Histone Acetyltransferase Gcn5 to Regulate Transcription, pp. 1142-1146
Wan-Sheng Lo; Laura Duggan; N. C. Tolga Emre; Rimma Belotserkovskya; William S. Lane; Ramin Shiekhattar; Shelley L. Berger
Argonaute2, a Link between Genetic and Biochemical Analyses of RNAi, pp. 1146-1150
Scott M. Hammond; Sabrina Boettcher; Amy A. Caudy; Ryuji Kobayashi; Gregory J. Hannon
Transitions in Distinct Histone H3 Methylation Patterns at the Heterochromatin Domain Boundaries, pp. 1150-1155
Ken-ichi Noma; C. David Allis; Shiv I. S. Grewal
Crystal Structure of a Neutralizing Human IgG against HIV-1: A Template for Vaccine Design, pp. 1155-1159
Erica Ollmann Saphire; Paul W. H. I. Parren; Ralph Pantophlet; Michael B. Zwick; Garrett M. Morris; Pauline M. Rudd; Raymond A. Dwek; Robyn L. Stanfield; Dennis R. Burton; Ian A. Wilson
Enforcement of Temporal Fidelity in Pyramidal Cells by Somatic Feed-Forward Inhibition, pp. 1159-1163
Frédéric Pouille; Massimo Scanziani
Expectation and Dopamine Release: Mechanism of the Placebo Effect in Parkinson's Disease, pp. 1164-1166
Raúl de la Fuente-Fernández; Thomas J. Ruth; Vesna Sossi; Michael Schulzer; Donald B. Calne; A. Jon Stoessl


Back Matter (42 pp.)

Previous Issue: New Series, Vol. 293, No. 5531, Aug. 3, 2001
Next Issue: New Series, Vol. 293, No. 5533, Aug. 17, 2001



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