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Science, New Series, Vol. 246, No. 4933, Nov. 24, 1989


Previous Issue: New Series, Vol. 246, No. 4932, Nov. 17, 1989
Next Issue: New Series, Vol. 246, No. 4934, Dec. 1, 1989


Front Matter (13 pp.)
The Choosing of the NIH Director, p. 981
Daniel E. Koshland


Perspective
Mechanisms of Immunological Tolerance, p. 982
H. Robson MacDonald
Retrovirus Vectors: Promise and Reality, p. 983
Howard M. Temin


Letters
Soviet-U.S. Seismological Data Exchange, p. 984
John R. Filson; Jon Peterson
BU ``Takeover'' of Chelsea Schools, p. 984
Bernard J. Fine
Top Quark Search, pp. 984-985
John Peoples
RU 486 Development, p. 985
Georges Teutsch; Paul P. Carbone
UCLA and Precollege Science, pp. 985+987
Arlene A. Russell
Correction: Recombinant 47-Kilodalton Cytosol Factor Restores NADPH Oxidase in Chronic Granulomatous Disease, p. 987
Karen J. Lomax; Thomas L. Leto; Hiroyuki Nunoi; John I. Gallin; Harry L. Malech


News & Comment
Hard Times at NIH, pp. 988-990
Joseph Palca
House Trims off Academic Pork, p. 990
Colin Norman
Soviet Sociology Makes a Comeback, pp. 991-992
Constance Holden
Global Warming: Blaming the Sun, pp. 992-993
Leslie Roberts
Dispute Surfaces over Paternity of RU 486, p. 994
Jeremy Cherfas


Research News
Playing Three-Dimensional Pool, pp. 995-997
Robert Pool
Galileo (Whew!) Changes Course, p. 997
M. Mitchell Waldrop
Readers Write to Right Wrongs, p. 997
Barry A. Cipra
A Passion for the Little Things among the Planets, pp. 998-999
Richard A. Kerr
Briefings, pp. 1000-1001
Colin Norman


The Origins of Ceramic Technology at Dolni Věstonice, Czechoslovakia, pp. 1002-1008
Pamela B. Vandiver; Olga Soffer; Bohuslav Klima; Jiři Svoboda

Chemical Cartography: Finding the Keys to the Kinetic Labyrinth, pp. 1009-1015
George W. Flynn

Parasitic Protozoa and Helminths: Biological and Immunological Challenges, pp. 1015-1022
Adel A. F. Mahmoud

Purification, Cloning, and Expression of Ciliary Neurotrophic Factor (CNTF), pp. 1023-1025
Leu-Fen H. Lin; Drzislav Mismer; Jack D. Lile; Lyman G. Armes; Eugene T. Butler; James L. Vannice; Frank Collins


Reports
Spatially Resolved Organic Analysis of the Allende Meteorite, pp. 1026-1029
Renato Zenobi; Jean-Michel Philippoz; Peter R. Buseck; Richard N. Zare
Covariance Mapping: A Correlation Method Applied to Multiphoton Multiple Ionization, pp. 1029-1031
L. J. Frasinski; K. Codling; P. A. Hatherly
Temperature and Sperm Incorporation in Polyploid Salamanders, pp. 1032-1034
James P. Bogart; Richard P. Elinson; Lawrence E. Licht
Similarity between the Transcriptional Silencer Binding Proteins ABF1 and RAP1, pp. 1034-1038
John F. X. Diffley; Bruce Stillman
A Nondeletional Mechanism of Thymic Self Tolerance, pp. 1038-1041
Fred Ramsdell; Tracy Lantz; B. J. Fowlkes
Failure of T Cell Receptor V β Negative Selection in an Athymic Environment, pp. 1041-1044
Richard J. Hodes; Susan O. Sharrow; Adam Solomon
Thymic Requirement for Clonal Deletion during T Cell Development, pp. 1044-1046
Alicia M. Fry; Lori A. Jones; Ada M. Kruisbeek; Louis A. Matis
DNA Topoisomerase I-Targeted Chemotherapy of Human Colon Cancer in Xenografts, pp. 1046-1048
Beppino C. Giovanella; John S. Stehlin; Monroe E. Wall; Mansukh C. Wani; Allan W. Nicholas; Leroy F. Liu; Robert Silber; Milan Potmesil


Technical Comments
Is Regulation of a Chloride Channel in Lymphocytes Affected in Cystic Fibrosis?, p. 1049
Grace Hagiwara; Mauri Krouse; Ulrike Müller; Jeffrey Wine
Is Regulation of a Chloride Channel in Lymphocytes Affected in Cystic Fibrosis?: Response, pp. 1049-1050
Phyllis Gardner; Howard Schulman
Sphingomyelin Synthase and PKC Activation, p. 1050
Randolph Y. Hampton; Olivier H. Morand
Sphingomyelin Synthase and PKC Activation: Response, p. 1050
Yusuf A. Hannun
Rab 12 kD, pp. 1050-1051
Peter Parham
Malaria Red Cell Cytoadherence, p. 1051
Eugene Roth; Dhananjaya K. Kaul; Ronald L. Nagel
Malaria Red Cell Cytoadherence: Response, p. 1051
Christian F. Ockenhouse; Narendra N. Tandon; Cathleen Magowan; G. A. Jamieson; Jeffrey D. Chulay


AAAS Annual Meeting Planner, pp. 1053-1059
Arthur Herschman


Meetings
Gordon Research Conferences - ``Frontiers of Science'', pp. 1060-1061


Book Reviews
Money Questions, p. 1062
The Financing of Biomedical Research
Eli Ginzberg; Anna B. Dutka
Review author[s]: Richard A. Rettig
Responses to Climate Change, pp. 1062-1063
Greenhouse Warming
Norman J. Rosenberg; William E. Easterling; Pierre R. Crosson; Joel Darmstadter
Review author[s]: John Firor
Health Differentials, pp. 1063-1064
Minorities and Cancer
Lovell A. Jones
Review author[s]: G. Marie Swanson
Enzyme Chemistry, pp. 1064-1065
Mechanistic Principles of Enzyme Activity
Joel F. Liebman; Arthur Greenberg
Environmental Influences and Recognition in Enzyme Chemistry
Joel F. Liebman; Arthur Greenberg
Review author[s]: Rowena G. Matthews
Nonlinearities, p. 1065
Order and Chaos in Nonlinear Physical Systems
Stig Lundqvist; Norman H. March; Mario P. Tosi
Review author[s]: Neal Abraham


Back Matter (24 pp.)

Previous Issue: New Series, Vol. 246, No. 4932, Nov. 17, 1989
Next Issue: New Series, Vol. 246, No. 4934, Dec. 1, 1989



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